Department of Clinical Health Science, Tokai University School of Medicine.
Tokai University Tokyo Hospital.
J Nutr Sci Vitaminol (Tokyo). 2020;66(4):289-295. doi: 10.3177/jnsv.66.289.
A high intake of green leafy vegetables rich in antioxidative nutrients such as vitamin C and β-carotene may protect against the risk of type 2 diabetes. Measurement of the circulating nutrient concentrations can indicate the nutrient status more directly, and vitamin C and carotenoids are recognized as good biomarkers for the intake of fruits and vegetables. The aim of this study was to investigate the relationships between serum antioxidative vitamin concentrations and type 2 diabetes in Japanese subjects. The study subjects comprised 506 men and 493 women who first underwent anti-aging health checks at Tokai University Tokyo Hospital. Serum concentration of vitamin (V) A, VC, α-tocoferol, β-carotene, VB12, folate, ferritin and homocysteine, and fasting plasma glucose and HbA1c were used for analysis. Low levels of β-carotene and VC were significantly associated with dysglycemia. Diabetic subjects showed significantly decreased β-carotene and VC levels, and multivariate analyses suggested that low levels of β-carotene and VC were factors related to diabetes. Low levels of β-carotene and VC are significantly related to dysglycemia/type 2 diabetes, and encouraging people at a higher risk of diabetes to take more green vegetables may be useful as a dietary intervention to improve the antioxidative vitamin status and dysglycemia.
大量摄入富含抗氧化营养素（如维生素 C 和β-胡萝卜素）的绿叶蔬菜可能有助于降低 2 型糖尿病的发病风险。测量循环营养素浓度可以更直接地反映营养素状况，维生素 C 和类胡萝卜素被认为是水果和蔬菜摄入量的良好生物标志物。本研究旨在调查日本人群血清抗氧化维生素浓度与 2 型糖尿病之间的关系。研究对象包括在东海大学东京医院首次进行抗衰老健康检查的 506 名男性和 493 名女性。分析了血清维生素（V）A、VC、α-生育酚、β-胡萝卜素、VB12、叶酸、铁蛋白和同型半胱氨酸以及空腹血糖和 HbA1c 的浓度。β-胡萝卜素和 VC 水平较低与糖代谢异常显著相关。糖尿病患者的β-胡萝卜素和 VC 水平明显降低，多变量分析表明，β-胡萝卜素和 VC 水平较低是与糖尿病相关的因素。β-胡萝卜素和 VC 水平较低与糖代谢异常/2 型糖尿病显著相关，鼓励糖尿病高危人群多吃绿叶蔬菜可能有助于改善抗氧化维生素状况和糖代谢异常。
