Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University (ABU), Zaria, Nigeria.
Ghana Med J. 2020 Mar;54(1):17-29. doi: 10.4314/gmj.v54i1.4.
This study aimed at evaluating the prevalence of hyperhomocysteinaemia in Northern-Nigerian hypertensives and its association with hypertension severity and some major determinants as data regarding these are lacking in sub-Saharan Africa.
A Community-based cross-sectional study done on 120 randomly-selected hypertensive patients who responded to an ABU radio frequency modulated invitation for free health-screening at the Ahmadu Bello University (ABU) Medical Centre from January 2016 to June 2016. The percentage of participants with high homocysteine levels, their anthropometric parameters and blood pressures were determined. Plasma homocysteine (hcy) was classified as normal (5-15), moderate (>15-30), intermediate (31-100) and severe (>100) µmol/L. Kruskal-Wallis test was applied and log-transformed homocysteine (LnHomocysteine) was correlated with systolic and diastolic blood pressures as well as age, body mass index, fasting blood glucose, glomerular filtration rate, hypertension duration and Lnfolate in males and females using the Pearson's Correlation analysis.
There were 83(69.2%) females and 37(30.8%) males with Median homocysteine of 20.8 µmol/L and 22.0 µmol/L respectively (p=0.003). Hyperhomocysteinaemia was found in 118(98.3%) hypertensives while 2(1.7%) subjects had normo-homocysteinaemia. Moderate hyperhomocysteinaemia (Median, 20.8 µmol/L) was identified in 105(87.5%) and intermediate (Median, 40 µmol/L) in 13(10.8%) (p<0.001). No subject had severe hyperhomocysteinaemia. Homocysteine was higher () in subjects with Stage 2 systolic hypertension. LnHomocysteine was significantly (p<0.001) correlated with blood pressure (SBP: r=0.45; DBP: r=0.40) and age (r=0.33).
The prevalence of hyperhomocysteinaemia in North-Western Nigerian hypertensives is high as against normal healthy controls. Plasma homocysteine is higher with severe systolic hypertension and positively associated with age.
No specific grants but Micro Nova Pharmaceuticals Limited, Nigeria and Emzor Pharmaceutical Industries, Lagos, Nigeria supported with drugs.
本研究旨在评估尼日利亚北部高血压患者高同型半胱氨酸血症的患病率，并探讨其与高血压严重程度及一些主要决定因素的相关性，因为撒哈拉以南非洲地区缺乏相关数据。
这是一项基于社区的横断面研究，共纳入 120 名随机选择的高血压患者，他们于 2016 年 1 月至 6 月期间响应阿布贾大学（ABU）医学中心的 ABU 射频调制邀请，参加了免费健康筛查。研究人员确定了参与者中高同型半胱氨酸水平的比例、他们的人体测量参数和血压。血浆同型半胱氨酸（hcy）分为正常（5-15）、中度（>15-30）、中间（31-100）和重度（>100）µmol/L。应用 Kruskal-Wallis 检验，对男性和女性的收缩压和舒张压以及年龄、体重指数、空腹血糖、肾小球滤过率、高血压病程和 Ln 叶酸与同型半胱氨酸进行相关性分析。
研究对象中女性 83 名（69.2%），男性 37 名（30.8%），其同型半胱氨酸中位数分别为 20.8µmol/L 和 22.0µmol/L（p=0.003）。118 名（98.3%）高血压患者存在高同型半胱氨酸血症，2 名（1.7%）患者同型半胱氨酸正常。105 名（87.5%）患者为中度高同型半胱氨酸血症（中位数 20.8µmol/L），13 名（10.8%）患者为中间型高同型半胱氨酸血症（中位数 40µmol/L）（p<0.001）。没有患者存在重度高同型半胱氨酸血症。2 级收缩期高血压患者的同型半胱氨酸水平更高。同型半胱氨酸与血压（SBP：r=0.45；DBP：r=0.40）和年龄（r=0.33）呈显著正相关（p<0.001）。
与正常健康对照组相比，尼日利亚西北部高血压患者高同型半胱氨酸血症的患病率较高。血浆同型半胱氨酸水平随严重收缩期高血压升高，并与年龄呈正相关。
本研究未获得特定的资助，但尼日利亚的 MicroNova 制药有限公司和拉各斯的 Emzor 制药工业有限公司提供了药物支持。
