Leuschner M, Leuschner U, Lazarovici D, Kurtz W, Hellstern A
Zentrum der Inneren Medizin, Johann Wolfgang Goethe-Universität, Frankfurt/Main, Federal Republic of Germany.
Gut. 1988 Apr;29(4):428-32. doi: 10.1136/gut.29.4.428.
In a controlled prospective double blind trial patients with cholesterol gall bladder stones are treated with ursodeoxy-cholic acid (group A: UDCA 11.1 mg/kg per day; n = 16) and Ursomenth respectively (group B: a mixture of UDCA/menthol: 4.75 mg/kg per day each; n = 17). With same stone number and size (10-12 mm) there is a complete dissolution rate in group A of 38%, and of 53% in group B within 15-16.9 months. The response rate (complete + partial dissolution) amounted to 75% and 76% respectively. In group A there is one case of stone calcification, in group B none. Both preparations are free of unwanted effects. This suggests that the cyclic monoterpene menthol enhances the effect of UDCA and is of comparable effect to a mixture of six different terpenes used in former times.
在一项对照前瞻性双盲试验中，对患有胆固醇性胆囊结石的患者分别使用熊去氧胆酸（A组：每天11.1毫克/千克熊去氧胆酸；n = 16）和熊薄荷醇（B组：熊去氧胆酸/薄荷醇混合物，各每天4.75毫克/千克；n = 17）进行治疗。结石数量和大小相同（10 - 12毫米）的情况下，A组在15 - 16.9个月内的完全溶解率为38%，B组为53%。有效率（完全 + 部分溶解）分别为75%和76%。A组有1例结石钙化，B组无。两种制剂均无不良反应。这表明环状单萜薄荷醇增强了熊去氧胆酸的效果，且效果与以前使用的六种不同萜类混合物相当。
