Neligan P, Bateson M C, Trash D B, Ross P E, Bouchier I A
Digestion. 1983;28(4):225-33. doi: 10.1159/000198992.
In a prospective dosage response study of 84 patients with radiolucent gall bladder stones treated with ursodeoxycholic acid (UDCA), a dose of 500 mg daily was as effective as 1,000 mg daily. Complete dissolution of stones was achieved in 9 of 31 patients (29%) treated for at least 6 months with the lower dose, and in 7 of 33 patients (21%) on the higher dose. 4 patients in each group continue on treatment having shown partial gall-stone dissolution. When the two dosage groups were considered together, small stones dissolved more readily than larger ones and, after allowance for stone size, success rates were equal in obese and non-obese patients. Treatment with UDCA was well tolerated and significant adverse effects were not encountered.
在一项对84例透光性胆囊结石患者使用熊去氧胆酸（UDCA）进行的前瞻性剂量反应研究中，每日500毫克的剂量与每日1000毫克的剂量效果相同。低剂量组31例患者中，9例（29%）接受至少6个月治疗后结石完全溶解；高剂量组33例患者中，7例（21%）结石完全溶解。每组各有4例患者在结石部分溶解后继续接受治疗。将两个剂量组综合考虑时，小结石比大结石更容易溶解，且在考虑结石大小因素后，肥胖患者和非肥胖患者的成功率相同。UDCA治疗耐受性良好，未出现明显不良反应。
