Xue Bing-Zhou, Xiang Wei, Zhang Qing, Wang Yi-Hao, Wang Hao-Fei, Yi Dong-Ye, Xiong Nan-Xiang, Jiang Xiao-Bing, Zhao Hong-Yang, Fu Peng
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Oncol Lett. 2020 Oct;20(4):83. doi: 10.3892/ol.2020.11944. Epub 2020 Aug 4.
Glioma is one of the most common types of tumor of the central nervous system. Due to the aggressiveness and invasiveness of high-level gliomas, the survival time of patients with these tumors is short, at ~15 months, even after combined treatment with surgery, radiotherapy and/or chemotherapy. Recently, a number of studies have demonstrated that long non-coding RNA (lncRNAs) serve crucial roles in the multistep development of human gliomas. Gliomas acquire numerous biological abilities during multistep development that collectively constitute the hallmarks of glioma. Thus, in this review, the roles of lncRNAs associated with glioma hallmarks and the current and future prospects for their development are summarized.
胶质瘤是中枢神经系统最常见的肿瘤类型之一。由于高级别胶质瘤具有侵袭性和浸润性，即使经过手术、放疗和/或化疗联合治疗，这些肿瘤患者的生存时间仍较短，约为15个月。最近，多项研究表明，长链非编码RNA（lncRNAs）在人类胶质瘤的多步骤发展中发挥着关键作用。胶质瘤在多步骤发展过程中获得了多种生物学能力，这些能力共同构成了胶质瘤的特征。因此，在本综述中，总结了与胶质瘤特征相关的lncRNAs的作用及其当前和未来的发展前景。
