Rynkeviciene Ryte, Simiene Julija, Strainiene Egle, Stankevicius Vaidotas, Usinskiene Jurgita, Miseikyte Kaubriene Edita, Meskinyte Ingrida, Cicenas Jonas, Suziedelis Kestutis
Nacional Cancer Institute, Santariskiu str. 1, LT-08660 Vilnius, Lithuania.
Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-08412 Vilnius, Lithuania.
Cancers (Basel). 2018 Dec 22;11(1):17. doi: 10.3390/cancers11010017.
Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes that regulate glioma initiation and progression. Recently, new data emerged, which shows that the cross-regulation between long non-coding RNAs and small non-coding RNAs contribute to phenotypic diversity of glioblastoma subclasses. In this paper, we review data of long non-coding RNA expression, which was evaluated in human glioma tissue samples during a five-year period. Thus, this review summarizes the following: (I) the role of non-coding RNAs in glioblastoma pathogenesis, (II) the potential application of non-coding RNA species in glioma-grading, (III) crosstalk between lncRNAs and miRNAs (IV) future perspectives of non-coding RNAs as biomarkers for glioma.
胶质瘤是中枢神经系统中最具侵袭性的脑肿瘤。胶质瘤细胞迁移、快速扩散并侵袭邻近正常组织的能力、其持续增殖以及异质性导致大多数高级别胶质瘤患者的总体生存期约为15个月。大量研究表明，非编码RNA在调节胶质瘤起始和进展的生物学过程中具有关键功能。最近，新的数据表明，长链非编码RNA和小非编码RNA之间的相互调节促成了胶质母细胞瘤亚类的表型多样性。在本文中，我们回顾了在五年期间对人类胶质瘤组织样本中长链非编码RNA表达进行评估的数据。因此，本综述总结如下：（I）非编码RNA在胶质母细胞瘤发病机制中的作用，（II）非编码RNA在胶质瘤分级中的潜在应用，（III）长链非编码RNA与微小RNA之间的相互作用，（IV）非编码RNA作为胶质瘤生物标志物的未来前景。
