Golay A, Zech L, Shi M Z, Chiou Y A, Reaven G M, Chen Y D
Department of Medicine, Stanford University School of Medicine.
Horm Metab Res. 1988 Jan;20(1):11-4. doi: 10.1055/s-2007-1010737.
These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, 125I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of 125I-LDL. These data demonstrated that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.
为了观察胰岛素缺乏是否会影响低密度脂蛋白（LDL）的分解代谢，已在四氧嘧啶诱导糖尿病的兔子身上开展了这些研究。结果显示，糖尿病兔子的血浆LDL胆固醇水平较低，同时LDL颗粒的胆固醇与蛋白质比率下降。此外，125I-LDL从糖尿病兔子血浆中消失的速度更慢，导致分解代谢率显著降低，125I-LDL的停留时间缩短。这些数据表明，胰岛素缺乏会极大地改变LDL的组成和分解代谢。
