孕期酒精的毒性和致畸作用。
Toxicant and teratogenic effects of prenatal alcohol.
作者信息
Mahnke Amanda H, Adams Amy M, Wang Andrew Z, Miranda Rajesh C
机构信息
Texas A&M University Health Science Center, Department of Neuroscience and Experimental Therapeutics, Bryan, TX 77807 USA.
出版信息
Curr Opin Toxicol. 2019 Apr;14:29-34. doi: 10.1016/j.cotox.2019.08.002. Epub 2019 Aug 21.
Abstract
Prenatal alcohol exposure can result in growth, cognitive, and behavioral deficits due to the toxicant and teratogenic effects of alcohol. Alcohol is an unusual toxicant, because, unlike other toxicants, it is consumed and has biological effects in the millimolar range. Cerebral cortical development is particularly vulnerable to both alcohol's acute and long-term reprogramming effects. Recent evidence suggests that neuroinflammation may be a persistent result of prenatal alcohol exposure and that modes of cellular communication capable of carrying miRNAs, such as extracellular vesicles, may be an integral part of long-term changes to cellular communication and inflammation following in utero alcohol exposure.
摘要
产前酒精暴露可因酒精的毒性和致畸作用导致生长、认知和行为缺陷。酒精是一种特殊的毒物，因为与其他毒物不同，它会被摄入并在毫摩尔范围内产生生物学效应。大脑皮质发育对酒精的急性和长期重编程效应尤为敏感。最近的证据表明，神经炎症可能是产前酒精暴露的持续后果，而能够携带微小RNA的细胞通讯模式，如细胞外囊泡，可能是子宫内酒精暴露后细胞通讯和炎症长期变化的一个组成部分。
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