食用植物在喀麦隆糖尿病防治中的重要性。

Importance of food plants in the prevention and treatment of diabetes in Cameroon.

作者信息

Tsabang Nole, Djeufack Lionel W Tsambang, Yedjou Clément G, Tchounwou Paul B

机构信息

Independent Consultant (Ex researcher of the Institute of Medical Researches and Medicinal Plants Studies (IMPM), Visiting lecturer at the University of Yaoundé I, Faculty of Medicine of Biomedical Science, at the University of Dschang, Faculty of Animal Biology and at the High Institute of Environmental Science, Yaounde-Cameroon.

Medical Doctor, Centre cardiologique Médicale, Po Box 13576 Yaounde, Cameroon.

出版信息

Bioact Compd Health Dis. 2019 Feb;2(2):11-26. doi: 10.31989/bchd.v2i2.554.

DOI:10.31989/bchd.v2i2.554

PMID:32864583

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7451804/

Abstract

BACKGROUND

Diabetes is a metabolic pathology that affects the human body's capacity to adequately produce and use insulin. Type 1 (insulin-dependent) diabetes accounts for 5-10 % of diabetic patients. In Type 2 diabetes the insulin produced by the pancreatic islets is not properly used by cells due to insulin resistance. Gestational diabetes sometimes occurs in pregnant women and affects about 18 % of all pregnancies.Diabetes is one of the most important multifactorial metabolic chronic diseases with fatal complications. According to the International Diabetes Federation's estimations in 2015, 415 million people had diabetes and there will be an increase to 642 million people by 2040. Although many ethnopharmacological surveys have been carried out in several parts of the world, no ethnomedical and ethnopharmacological surveys have been done to identify plants used for the prevention and treatment of diabetes.

OBJECTIVE

This study aimed to collect and document information on food plants' remedies consumed for the prevention and treatment of diabetes in Cameroon.

METHODS

Ethnomedical and ethnopharmacological thorough preparations were conducted with 1131 interviewees from 58 tribes, following a random distribution. Diabetic patients recorded among this sample signed the informed consent and allowed us to evaluate the effectiveness of 10 identified food plants usually used for self-medication. They were divided into two groups: Group 1 comprised of 42 diabetic patients who regularly consume certain of these food plants, and Group 2 included 58 patients who were town-dwellers and did not regularly eat these identified food plants.

RESULTS

It was recorded that the onset of diabetes in patients were at about 70 years and 45 years for Group 1 and Group 2 respectively. Hence, a relationship was demonstrated between the onset of diabetes and the consumption of food plants. They contributed to the prevention and/or the delay in clinical manifestations.

CONCLUSION

Further investigations and/or clinical trials involving a large number of both type 1 and type 2 diabetics are needed to describe the therapeutic action of many food plants against diabetes. However, this study provides scientific support for the use of herbal medicines in the management of diabetes.

摘要

背景

糖尿病是一种代谢性疾病，会影响人体充分产生和利用胰岛素的能力。1型（胰岛素依赖型）糖尿病占糖尿病患者的5% - 10%。在2型糖尿病中，由于胰岛素抵抗，胰岛产生的胰岛素不能被细胞正常利用。妊娠期糖尿病有时会发生在孕妇身上，约占所有妊娠的18%。糖尿病是最重要的多因素代谢性慢性疾病之一，会引发致命并发症。根据国际糖尿病联盟2015年的估计，有4.15亿人患有糖尿病，到2040年这一数字将增至6.42亿。尽管世界上多个地区都进行了许多民族药理学调查，但尚未开展民族医学和民族药理学调查来确定用于预防和治疗糖尿病的植物。

目的

本研究旨在收集并记录喀麦隆用于预防和治疗糖尿病的食用植物疗法的相关信息。

方法

对来自58个部落的1131名受访者进行了民族医学和民族药理学的全面准备工作，受访者为随机抽取。在该样本中记录的糖尿病患者签署了知情同意书，并允许我们评估10种常用于自我治疗的已确定食用植物的有效性。他们被分为两组：第1组由42名经常食用这些食用植物中的某些植物的糖尿病患者组成，第2组包括58名城市居民，他们不经常食用这些已确定的食用植物。