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出院的 COVID-19 患者中再出现阳性核酸检测结果的流行率和结局。

Prevalence and outcomes of re-positive nucleic acid tests in discharged COVID-19 patients.

机构信息

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China.

Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.

出版信息

Eur J Clin Microbiol Infect Dis. 2021 Feb;40(2):413-417. doi: 10.1007/s10096-020-04024-1. Epub 2020 Aug 31.

Abstract

The prevalence and outcomes of patients who had re-activation of coronavirus disease 2019 (COVID-19) after discharge remain poorly understood. We included 126 consecutively confirmed cases of COVID-19 with 2-month follow-up data after discharge in this retrospective study. The upper respiratory specimen using a reverse-transcription polymerase chain reaction test of three patients (71 years [60-76]) were positive within 11-20 days after their discharge, with an event rate of 19.8 (95%CI 2.60-42.1) per 1,000,000 patient-days. Moreover, all re-positive patients were asymptomatic. Our findings suggest that few recovered patients may still be virus carriers even after reaching the discharge criteria.

摘要

出院后 COVID-19(新型冠状病毒肺炎)再次发作患者的发病情况和结局仍不清楚。我们在这项回顾性研究中纳入了 126 例连续确诊的 COVID-19 患者,他们在出院后有 2 个月的随访数据。3 名患者(71 岁[60-76]岁)出院后 11-20 天内使用逆转录聚合酶链反应检测上呼吸道标本,其阳性事件发生率为每 100 万患者日 19.8(95%CI 2.60-42.1)。此外,所有再次阳性的患者均无症状。我们的研究结果表明,即使达到出院标准,少数康复患者仍可能是病毒携带者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e026/7456660/dcecba60a163/10096_2020_4024_Fig1_HTML.jpg

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