Department of Clinical Diagnostic Centre, the Fifth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, People's Republic of China.
The GREY Bush Community Health Center, Grey Bush, Ascension-town, Sierra Leone.
Int J Legal Med. 2021 May;135(3):767-769. doi: 10.1007/s00414-020-02417-7. Epub 2020 Aug 31.
As the origin of modern humanity, African populations show high genetic diversity and are attracting increasing academic attention. However, populations living in West Africa have so far received less study and exploration. In this study, we analyze 30 insertion/deletion (InDel) loci of 516 samples from Freetown, Sierra Leone, to evaluate the forensic properties and reveal the genetic structure in Freetown, Sierra Leone, West Africa. No significant linkage disequilibrium (LD) between 30 InDels was observed after the Bonferroni correction. The random match probability (RMP), the combined power of exclusion for duos (CPE duos), and the combined power of exclusion for trios (CPE trios) were 6.823 × 10, 0.9168, and 0.9731, respectively. Null alleles and off-ladder alleles were observed, suggesting that we should be cautious when using this kit for forensic caseworks in African populations. In the population comparison study, we found that the Freetown population is genetically closer to geographically distinct West Africans and has a closer genetic relationship with the Bantu-speaking populations than other African populations.
作为现代人类的起源地，非洲人群表现出高度的遗传多样性，因此越来越受到学术界的关注。然而，迄今为止，生活在西非的人群受到的研究和探索较少。在这项研究中，我们分析了来自塞拉利昂弗里敦的 516 个样本中的 30 个插入/缺失（InDel）位点，以评估弗里敦的法医学特性并揭示其遗传结构。经过 Bonferroni 校正后，30 个 InDels 之间没有观察到显著的连锁不平衡（LD）。随机匹配概率（RMP）、双等位基因排除的综合效能（CPE duos）和三等位基因排除的综合效能（CPE trios）分别为 6.823×10^-9、0.9168 和 0.9731。观察到了无效等位基因和梯外等位基因，这表明在使用该试剂盒进行非洲人群的法医学案例工作时应谨慎。在群体比较研究中，我们发现弗里敦人群在遗传上与地理位置不同的西非人群更为接近，与讲班图语的人群的遗传关系比其他非洲人群更为密切。
