Department of Forensic Science, School of Basic Medical Sciences, Central South University, No 172. Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.
Int J Legal Med. 2021 Mar;135(2):455-456. doi: 10.1007/s00414-020-02487-7. Epub 2021 Jan 6.
Population genetic analysis is of vital importance for personal identification and paternity testing in forensic science. However, the forensic characteristics of autosomal short tandem repeat (STR) loci in the Sierra Leone population have not been reported yet to the best of our knowledge. In this study, 528 unrelated individuals (256 males and 272 females) in Sierra Leone, West Africa, were genotyped using the DNA Typer19™ kit; forensic parameters and genetic relationships with 32 populations around the world were analyzed. A total of 239 alleles were detected, with corresponding allele frequencies ranged from 0.0009 to 0.4545. The cumulative power of discrimination (CPD) value of the 18 STR loci was 0.9999999999999999999999697; the cumulative probability of exclusion for duos (CPE ) and exclusion for trios (CPE ) were 0.99999343 and 0.9999999895, respectively. Genetic comparisons showed that the Sierra Leone population has a closer genetic relationship with the Bantu-speaking populations in Sub-Saharan Africa.
群体遗传学分析对于法医学中的个体识别和亲子鉴定至关重要。然而，据我们所知，塞拉利昂人群的常染色体短串联重复（STR）位点的法医学特征尚未有报道。在这项研究中，我们使用 DNA Typer19™试剂盒对来自西非塞拉利昂的 528 名无关个体（256 名男性和 272 名女性）进行了基因分型；分析了法医学参数以及与全球 32 个人群的遗传关系。共检测到 239 个等位基因，相应的等位基因频率范围为 0.0009 至 0.4545。18 个 STR 位点的累积鉴别力（CPD）值为 0.9999999999999999999999697；双生子排除概率（CPE）和三胞胎排除概率（CPE）分别为 0.99999343 和 0.9999999895。遗传比较表明，塞拉利昂人群与撒哈拉以南非洲的班图语人群具有更密切的遗传关系。
