García Torres Edgar, Pérez Morales Rebeca, González Zamora Alberto, Ríos Sánchez Efraín, Olivas Calderón Edgar Héctor, Alba Romero José de Jesús, Calleros Rincón Esperanza Yasmín
Doctorado en Ciencias Biomédicas. Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Gómez Palacio, Durango, México.
Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Gómez Palacio, Durango, México.
Int J Environ Health Res. 2022 May;32(5):984-1001. doi: 10.1080/09603123.2020.1815664. Epub 2020 Aug 31.
Nowadays, the nitrates have been established as carcinogenic components due to the endogenous formation of -nitroso compounds, however, the consumption of water contaminated with nitrates has only been strongly related to the presence of methemoglobinemia in infants, as an acute effect, leaving out other side effects that demand attention. The thyroid gland takes relevance because it can be altered by many pollutants known as endocrine disruptors, which are agents capable of interfering with the synthesis of hormones, thus far, it is known that nitrates may disrupt the amount of iodine uptake causing most of the time hypothyroidism and affecting the metabolic functions of the organism in all development stages, resulting in an important health burden for the exposed population. Here, this review and update highlighted the impact of consumption of water contaminated with nitrates and effects on the thyroid gland in humans, concluding that nitrates could act as true endocrine disruptor.
如今，由于内源性亚硝基化合物的形成，硝酸盐已被确认为致癌成分。然而，饮用受硝酸盐污染的水仅与婴儿高铁血红蛋白血症的发生密切相关，这是一种急性效应，而忽略了其他需要关注的副作用。甲状腺具有相关性，因为它会受到许多被称为内分泌干扰物的污染物的影响，这些物质能够干扰激素的合成。到目前为止，已知硝酸盐可能会干扰碘的摄入量，大多数情况下会导致甲状腺功能减退，并影响生物体在所有发育阶段的代谢功能，给暴露人群带来重要的健康负担。在此，本综述及更新强调了饮用受硝酸盐污染的水的影响以及对人体甲状腺的作用，得出结论：硝酸盐可能是真正的内分泌干扰物。
