Bruning-Fann C S, Kaneene J B
Population Medicine Center, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Vet Hum Toxicol. 1993 Dec;35(6):521-38.
The effects of nitrate, nitrite, and N-nitroso compounds on human health are reviewed. Special emphasis has been placed on the role of these compounds on infant methemoglobinemia and gastric cancer. The discussion on methemoglobinemia includes the source of nitrate or nitrite, diagnosis, treatment, prevention and the contributions of age, gastric pH, gastrointestinal illness, and ingestion of vitamin C to this illness. The maternal transfer of these compounds and the potential effect on fetal death and malformation are also described. The etiology and development of gastric cancer is reviewed as well as the roles of nitrate, nitrite, and N-nitroso compounds in this disease. Endogenous nitrosation and the experimental and epidemiologic evidence linking these compounds to gastric cancer is examined. Other sections include adult methemoglobinemia and acute toxicity, hypo- and hypertension, Balkan nephropathy, slowing of motor reflexes in children, nitrate esters dependence. Sources of nitrate, nitrite, and N-nitroso compounds are detailed. Future areas of research are given.
本文综述了硝酸盐、亚硝酸盐和N-亚硝基化合物对人体健康的影响。特别强调了这些化合物在婴儿高铁血红蛋白血症和胃癌中的作用。关于高铁血红蛋白血症的讨论包括硝酸盐或亚硝酸盐的来源、诊断、治疗、预防以及年龄、胃pH值、胃肠道疾病和维生素C摄入对该疾病的影响。还描述了这些化合物的母体转移以及对胎儿死亡和畸形的潜在影响。本文还综述了胃癌的病因和发展，以及硝酸盐、亚硝酸盐和N-亚硝基化合物在该疾病中的作用。研究了内源性亚硝化作用以及将这些化合物与胃癌联系起来的实验和流行病学证据。其他部分包括成人高铁血红蛋白血症和急性毒性、低血压和高血压、巴尔干肾病、儿童运动反射减慢、硝酸酯依赖。详细介绍了硝酸盐、亚硝酸盐和N-亚硝基化合物的来源。给出了未来的研究领域。
