Montes Angeles Claudia Daniela, Andrade Gonzalez Rey David, Hernandez Elias Perrusquia, García Hernández Ana Lilia, Pérez Martínez Isaac Obed
Student/Resident, Sección de neurobiología de las sensaciones orales, Laboratorio de Investigación odontológica, Clínica Universitaria de Salud Integral Almaraz, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, México.
Student/Resident, Research Professor, Sección de Osteoinmunología, Laboratorio de Investigación odontológica, Clínica Universitaria de Salud Integral Almaraz, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, México.
J Oral Maxillofac Surg. 2020 Dec;78(12):2169-2181. doi: 10.1016/j.joms.2020.07.212. Epub 2020 Aug 5.
To characterize adequate study of chronic neuropathic orofacial pain induced by a mental nerve injury in a mouse model, we propose a behavioral assessment of its dimensions: sensory, affective, and cognitive.
Trigeminal injury was induced by a chronic mental nerve constriction (MnC). Behavioral tests were conducted to assess the different dimensions of pain and to evaluate the general well-being of mice.
Rodents who went through MnC showed signs of mechanical hyperalgesia and increased escape/avoidance behavior. They showed no alterations in general well-being behaviors, yet the injury was sufficient to induce impairment in the ability to adapt to the environmental requirements.
MnC injury is an efficient model for the study of orofacial pain in mice, capable of inducing impairment in the different dimensions of pain. Intensity and temporality of its effects make our model less aggressive, yet effective to generate cognitive impairment. This work provides a solid foundation for the study of the neural circuits involved in the processing of neuropathic orofacial pain.
为了在小鼠模型中充分研究精神神经损伤引起的慢性神经性口面部疼痛，我们提出了对其维度（感觉、情感和认知）的行为评估。
通过慢性颏神经缩窄（MnC）诱导三叉神经损伤。进行行为测试以评估疼痛的不同维度，并评估小鼠的总体健康状况。
经历MnC的啮齿动物表现出机械性痛觉过敏和逃避/回避行为增加。它们在总体健康行为方面没有变化，但损伤足以导致适应环境要求的能力受损。
MnC损伤是研究小鼠口面部疼痛的有效模型，能够在疼痛的不同维度上诱导损伤。其作用的强度和时间性使我们的模型攻击性较小，但能有效产生认知障碍。这项工作为研究参与神经性口面部疼痛处理的神经回路提供了坚实的基础。
