Department of Oral Health Care Promotion, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto, Tokushima 770-8504, Japan.
Department of Oral Biology & Diagnostic Sciences, The Dental College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Int J Mol Sci. 2020 Aug 27;21(17):6207. doi: 10.3390/ijms21176207.
Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. It has recently been shown that there is correlation between intestinal bacteria and cancer development including metastasis. As over 700 bacterial species exist in an oral cavity, it has been concerning that bacterial infection may cause oral cancer. However, the role of bacteria regarding tumorigenesis of oral cancer remains unclear. Several papers have shown that species deriving the oral cavities, especially, play a crucial role for the development of colorectal and esophageal cancer. is a well-known oral bacterium involved in formation of typical dental plaque on human teeth and causing periodontal diseases. The greatest characteristic of is its ability to adhere to various bacteria and host cells. Interestingly, is frequently detected in oral cancer tissues. Moreover, detection of is correlated with the clinical stage of oral cancer. Although the detailed mechanism is still unclear, species have been suggested to be associated with cell adhesion, tumorigenesis, epithelial-to-mesenchymal transition, inflammasomes, cell cycle, etc. in oral cancer. In this review, we introduce the reports focused on the association of species with cancer development and progression including oral, esophageal, and colon cancers.
慢性炎症是由感染引起的，据认为是癌症最重要的原因之一。最近已经表明，肠道细菌与癌症的发展包括转移之间存在相关性。由于口腔中有超过 700 种细菌存在，人们一直担心细菌感染可能会导致口腔癌。然而，细菌在口腔癌发生中的作用尚不清楚。有几篇论文表明，口腔中的细菌，特别是某些细菌，在结直肠癌和食管癌的发展中起着关键作用。是一种众所周知的口腔细菌，参与人类牙齿上典型牙菌斑的形成，并导致牙周病。的最大特点是它能够附着在各种细菌和宿主细胞上。有趣的是，在口腔癌组织中经常检测到。此外，的检测与口腔癌的临床分期相关。虽然详细的机制尚不清楚，但已经有研究表明，口腔细菌与口腔癌中的细胞黏附、肿瘤发生、上皮-间充质转化、炎性小体、细胞周期等有关。在这篇综述中，我们介绍了专注于口腔、食管和结肠癌中与癌症发展和进展相关的口腔细菌的报告。
