Department of Oral and Maxillofacial Surgery, College of Dentistry, New York University, New York, NY 10010, USA.
Department of Cariology and Comprehensive Care, College of Dentistry, New York University, New York, NY 10010, USA.
Int J Mol Sci. 2020 Aug 27;21(17):6217. doi: 10.3390/ijms21176217.
Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. , , , , , and were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.
尽管文献中有许多关于表观遗传机制在牙周病中的作用的报道，但需要对已发表的研究进行全面评估，以便更好地理解表观遗传变化与牙周病及其治疗之间关系的证据。因此，本系统评价的目的是确定并综合与人类成年人牙周病和牙周病治疗相关的 DNA 甲基化/组蛋白修饰的证据。独立进行了系统搜索以确定符合纳入标准的文章。评估了与牙周病相关的 DNA 甲基化和组蛋白修饰、基因表达、牙周治疗后的表观遗传变化以及表观遗传学与临床参数之间的关联。确定了 16 项研究。所有纳入的研究都检查了与牙周炎相关的 DNA 修饰，没有一项研究检查了组蛋白修饰。在报告样本量和患者特征、统计分析和方法方面存在很大差异。尽管不一致，但有一些证据表明 DNA 甲基化与牙周病之间存在关联。 、 、 、 、 和 被确定为评估牙周炎中 DNA 甲基化的候选基因。虽然一些纳入的研究发现了甲基化水平与牙周病风险之间的关联，但没有足够的证据支持或反驳 DNA 甲基化与人类成年人牙周病/治疗之间的关联。必须进行进一步的研究，以确定可重复的表观遗传标志物，并确定 DNA 甲基化在多大程度上可以作为临床生物标志物。
