Franco Cavalla, Patricia Hernández-Ríos, Timo Sorsa, Claudia Biguetti, Marcela Hernández
Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile.
Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo (FOB/USP), Bauru, São Paulo 17012-901, Brazil.
Int J Mol Sci. 2017 Feb 17;18(2):440. doi: 10.3390/ijms18020440.
Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the 'protease web' is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules-such as cytokines, chemokines, and growth factors, among others-regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.
牙周炎是一种以免疫介导的牙周支持组织破坏和牙齿脱落为特征的感染性疾病。基质金属蛋白酶（MMPs）是参与破坏性牙周疾病的关键蛋白酶。越来越多的证据表明，MMPs能够切割多种分子，并可能调节无数的生物学过程，这激发了人们对MMPs的研究兴趣。在“蛋白酶网络”中，MMPs功能的巨大复杂性对许多生理和病理过程至关重要，包括免疫、炎症、骨吸收和伤口愈合。有证据表明，MMPs在激活级联反应中聚集，除了其经典的细胞外基质底物外，它们还能切割多种信号分子，如细胞因子、趋化因子和生长因子等，在牙周疾病期间调节它们的生物学功能和/或生物利用度。在这篇综述中，我们概述了MMPs作为牙周炎症调节因子的新证据。
