免疫调节细胞因子基因甲基化与胰腺癌结局。
Methylation of immune-regulatory cytokine genes and pancreatic cancer outcomes.
机构信息
Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA.
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA.
出版信息
Epigenomics. 2020 Aug;12(15):1273-1285. doi: 10.2217/epi-2019-0335. Epub 2020 Sep 1.
Abstract
Given the immunosuppressive nature of pancreatic cancer, we investigated the relationship between epigenetic modification of immune-regulatory cytokine genes and pancreatic cancer outcomes. We evaluated DNA methylation of 184 pancreatic tumor samples from The Cancer Genome Atlas for 111 CpG loci in seven cytokine genes: , , , , , and . We used Cox regression to evaluate the associations between methylation and overall survival, disease-specific survival and disease progression (α = 0.05). Poorer survival was associated with increased methylation in fifteen CpG probes in , , and . We also detected improved outcomes for three loci in , and . Epigenetic regulation of cytokine-related gene expression may be associated with pancreatic cancer outcomes.
摘要
鉴于胰腺癌的免疫抑制特性，我们研究了免疫调节细胞因子基因的表观遗传修饰与胰腺癌结局之间的关系。我们评估了来自癌症基因组图谱的 184 个胰腺肿瘤样本中 7 个细胞因子基因（、、、、、和）的 111 个 CpG 位点的 DNA 甲基化。我们使用 Cox 回归来评估甲基化与总生存、疾病特异性生存和疾病进展之间的关联（α=0.05）。在、和中，有 15 个 CpG 探针的甲基化与生存率下降相关。我们还在、和中检测到三个位点的预后改善。细胞因子相关基因表达的表观遗传调控可能与胰腺癌的结局有关。
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