Qin Qiaojing, Yang Min, Ke Wencai, Zhao Jinying, Ding Heyuan
Department of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
J Int Med Res. 2020 Aug;48(8):300060520952973. doi: 10.1177/0300060520952973.
The aim of our study was to explore the association between serum cystatin C (CysC) and euthyroid Hashimoto's thyroiditis.
There were 119 female euthyroid Hashimoto's thyroiditis patients and 225 healthy controls who were recruited. Serum CysC, thyroid function, thyroid autoantibodies, fasting glucose, liver enzymes, and lipid profile were determined. Clinical parameters were compared between two groups.
Serum CysC levels were significantly higher in euthyroid Hashimoto's thyroiditis patients compared with controls. In the lowest, middle, and highest tertile groups of CysC, the percentage of Hashimoto's thyroiditis was 15.9%, 34.2%, and 53.5%, respectively. The percentage of Hashimoto's thyroiditis was significantly higher in the highest tertile than in the lowest and middle tertiles. Spearman's correlation analysis showed that serum CysC levels were negatively correlated with free triiodothyronine (FT), and positively correlated with serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). Logistic regression analysis showed that serum CysC was independently related to the status of euthyroid Hashimoto's thyroiditis.
The present study shows the first evidence suggesting that serum CysC levels are positively correlated with TPOAb and TGAb. Serum CysC might underlie the pathophysiologic features of euthyroid Hashimoto's thyroiditis.
本研究旨在探讨血清胱抑素C（CysC）与甲状腺功能正常的桥本甲状腺炎之间的关联。
招募了119例甲状腺功能正常的桥本甲状腺炎女性患者和225例健康对照者。测定血清CysC、甲状腺功能、甲状腺自身抗体、空腹血糖、肝酶和血脂谱。比较两组的临床参数。
与对照组相比，甲状腺功能正常的桥本甲状腺炎患者血清CysC水平显著升高。在CysC的最低、中间和最高三分位数组中，桥本甲状腺炎的百分比分别为15.9%、34.2%和53.5%。最高三分位数组中桥本甲状腺炎的百分比显著高于最低和中间三分位数组。Spearman相关性分析显示，血清CysC水平与游离三碘甲状腺原氨酸（FT）呈负相关，与血清甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）呈正相关。Logistic回归分析显示，血清CysC与甲状腺功能正常的桥本甲状腺炎状态独立相关。
本研究首次表明血清CysC水平与TPOAb和TGAb呈正相关。血清CysC可能是甲状腺功能正常的桥本甲状腺炎病理生理特征的基础。
