Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze, Katowice, Poland.
Endokrynol Pol. 2010 Jan-Feb;61(1):112-6.
Leptin and adiponectin are involved in the pathogenesis of several autoimmune diseases. Very little is known about adipocytokine production in autoimmune thyroid diseases. Interleukin-6 (IL-6) plays an important role in the inflammatory and autoimmune processes.
The aim of this study was to assess the serum levels of leptin, adiponectin, and IL-6 in postmenopausal euthyroid women with Hashimoto's thyroiditis and compared them with concentrations in control women. Ninety-eight euthyroid women with Hashimoto's thyroiditis were enrolled in the study. The diagnosis was confirmed with elevated thyroid peroxidise autoantibody (TPOAb) levels in serum and typical hypoechogenic pattern on thyroid ultrasound. The control group, matched for body mass index (BMI), consisted of 105 healthy postmenopausal euthyroid women. Serum levels of leptin, adiponectin, IL-6, thyroid-stimulating hormone (TSH), free thyroxine (fT(4)), and TPOAbs were determined.
When compared with controls, the women with Hashimoto's thyroiditis were characterized by significantly elevated serum concentrations of IL-6, whereas concentrations of leptin and adiponectin were not different. Hashimoto's thyroiditis patients had significantly higher serum levels of TSH than the controls. The simple linear regression analyses of the Hashimoto's thyroiditis group and all of the studied women indicated that serum leptin levels correlated positively with BMI, waist to hip ratio (WHR), TSH, and IL-6 and negatively with adiponectin. No correlation was observed between serum adiponectin and TSH, fT(4), or TPOAbs. There were no associations between serum IL-6 levels, TPOAbs, and TSH levels; however, positive correlations between IL-6 and BMI, WHR, and leptin were observed. TSH correlated positively with leptin, age, and TPOAbs.
Hashimoto's thyroiditis is characterized by an increased production of IL-6 but does not have a direct influence on leptin or adiponectin serum levels. The correlations between TSH and leptin demonstrated in this study highlight the need for future investigations. (Pol J Endocrinol 2010; 61 (1): 112-116).
瘦素和脂联素参与了多种自身免疫性疾病的发病机制。关于自身免疫性甲状腺疾病中脂联素的产生知之甚少。白细胞介素-6（IL-6）在炎症和自身免疫过程中起着重要作用。
本研究旨在评估绝经后甲状腺功能正常的桥本甲状腺炎妇女的血清瘦素、脂联素和白细胞介素-6水平，并将其与对照组妇女的浓度进行比较。本研究纳入了 98 例甲状腺功能正常的桥本甲状腺炎妇女。通过血清甲状腺过氧化物酶自身抗体（TPOAb）水平升高和甲状腺超声典型低回声模式来确诊。对照组为 105 名年龄和体重指数（BMI）匹配的健康绝经后甲状腺功能正常的妇女。测定血清瘦素、脂联素、白细胞介素-6、促甲状腺激素（TSH）、游离甲状腺素（fT（4））和 TPOAbs 水平。
与对照组相比，桥本甲状腺炎患者的血清白细胞介素-6浓度显著升高，而瘦素和脂联素浓度无差异。桥本甲状腺炎患者的血清 TSH 水平明显高于对照组。桥本甲状腺炎组和所有研究妇女的简单线性回归分析表明，血清瘦素水平与 BMI、腰臀比（WHR）、TSH 和白细胞介素-6呈正相关，与脂联素呈负相关。血清脂联素与 TSH、fT（4）或 TPOAbs 之间无相关性。血清白细胞介素-6水平、TPOAbs 与 TSH 水平之间无相关性，但白细胞介素-6与 BMI、WHR 和瘦素呈正相关。TSH 与瘦素、年龄和 TPOAbs 呈正相关。
桥本甲状腺炎的特点是白细胞介素-6产生增加，但对瘦素或脂联素血清水平没有直接影响。本研究中观察到的 TSH 与瘦素之间的相关性突出了未来研究的必要性。（波兰内分泌学会杂志 2010；61（1）：112-116）。
