Yang Yanjiang, Li Renpeng, Yang Wenwen
Department of Rheumatology and Immunology, The People's Hospital of Qiandongnan Autonomous Prefecture, Guizhou Medical University, Kaili, 556000, Guizhou Province, China.
The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Obes Surg. 2025 Mar;35(3):902-914. doi: 10.1007/s11695-025-07681-3. Epub 2025 Feb 4.
Obesity is increasingly prevalent worldwide and has been linked to various health conditions, including hypothyroidism.
Summary-level GWAS data from the UK Biobank and the FinnGen Biobank were used for Mendelian randomization analysis. The impact of BMI on autoimmune hypothyroidism through putative mediators was assessed through a four-step analytical process. Statistical analyses, including the inverse-variance-weighted (IVW) method, weighted median (WM), and MR-Egger methods, were employed to evaluate causal relationships and detect horizontal pleiotropy. Mediation analysis was performed using a two-step method to assess the causal relationships between BMI, putative mediators, and autoimmune hypothyroidism.
Higher BMI was associated with an increased risk of autoimmune hypothyroidism. Mean corpuscular volume, eosinophil count, and cystatin C levels were found to mediate this association.
BMI positively correlates with autoimmune hypothyroidism, with mean corpuscular volume, eosinophil count, and cystatin C levels mediating this relationship. Further research is needed to confirm these findings and explore causal relationships across diverse populations.
肥胖在全球范围内日益普遍，并与包括甲状腺功能减退在内的各种健康状况相关联。
使用来自英国生物银行和芬兰基因生物银行的汇总水平全基因组关联研究（GWAS）数据进行孟德尔随机化分析。通过一个四步分析过程评估体重指数（BMI）通过假定介质对自身免疫性甲状腺功能减退的影响。采用包括逆方差加权（IVW）方法、加权中位数（WM）和MR-Egger方法在内的统计分析来评估因果关系并检测水平多效性。使用两步法进行中介分析，以评估BMI、假定介质和自身免疫性甲状腺功能减退之间的因果关系。
较高的BMI与自身免疫性甲状腺功能减退风险增加相关。发现平均红细胞体积、嗜酸性粒细胞计数和胱抑素C水平介导了这种关联。
BMI与自身免疫性甲状腺功能减退呈正相关，平均红细胞体积、嗜酸性粒细胞计数和胱抑素C水平介导了这种关系。需要进一步研究以证实这些发现并探索不同人群中的因果关系。
