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膝下动脉栓塞术改善早期膝关节骨关节炎疼痛和功能——24个月的初步研究结果

Genicular Artery Embolization to Improve Pain and Function in Early-Stage Knee Osteoarthritis-24-Month Pilot Study Results.

作者信息

Landers Steve, Hely Rachael, Page Richard, Maister Nick, Hely Andrew, Harrison Benjamin, Gill Stephen

机构信息

Barwon Medical Imaging, University Hospital Geelong, Barwon Health, Bellerine Street, Geelong, Victoria 3220, Australia; GIRADI Research Institute, Geelong, Victoria, Australia.

Barwon Medical Imaging, University Hospital Geelong, Barwon Health, Bellerine Street, Geelong, Victoria 3220, Australia; GIRADI Research Institute, Geelong, Victoria, Australia.

出版信息

J Vasc Interv Radiol. 2020 Sep;31(9):1453-1458. doi: 10.1016/j.jvir.2020.05.007.

DOI:10.1016/j.jvir.2020.05.007
PMID:32868019
Abstract

Ten patients with painful early-stage knee osteoarthritis underwent transcatheter arterial embolization of neoangiogenic branches from genicular arteries. At 12 months, 6 patients had responded to treatment according to study criteria. Median pain, function, and quality-of-life scores had improved by 15.4%, 21.3%, and 100%, respectively, for the 10 patients. Median 30-second chair stand test and 6-minute walk test scores had improved by 43% and 26%, respectively. No major adverse events occurred. Improvements following transcatheter arterial embolization provide evidence that embolization might be an effective treatment technique for people with early-stage knee osteoarthritis, although more rigorous evaluation is required.

摘要

10例早期膝关节骨性关节炎疼痛患者接受了经导管动脉栓塞术,栓塞膝动脉新生血管分支。12个月时,根据研究标准,6例患者治疗有效。10例患者的疼痛、功能和生活质量评分中位数分别提高了15.4%、21.3%和100%。30秒椅子站立试验和6分钟步行试验评分中位数分别提高了43%和26%。未发生重大不良事件。经导管动脉栓塞术后的改善表明,栓塞术可能是早期膝关节骨性关节炎患者的一种有效治疗技术,尽管还需要更严格的评估。

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