Pfau A, Sacks T G, Shapiro M
Department of Urology (Urinary Tract Infection Unit), Hebrew University Hadassah Medical Center, Jerusalem, Israel.
J Urol. 1988 Jun;139(6):1250-2. doi: 10.1016/s0022-5347(17)42881-3.
A total of 21 sexually active premenopausal women, prone to recurrent urinary tract infections but who otherwise were healthy, underwent post-coital prophylaxis consisting of bladder voiding and a single 250 mg. tablet of cinoxacin. While 94 urinary tract infections occurred during a mean of 7.5 months before treatment, only 8 occurred during a mean of 12.5 months after prophylaxis. This difference was statistically highly significant. A mean of 106 cinoxacin tablets per patient were administered during post-coital prophylaxis. Cinoxacin represents an additional valuable and effective antibacterial in post-coital prophylaxis of recurrent urinary tract infection in otherwise healthy premenopausal women, although it is slightly less effective than cotrimoxazole or nitrofurantoin. Effective post-coital prophylaxis requires the use of much smaller quantities of antibacterial agents than the daily use of a single tablet and in women with a high incidence of recurrent urinary tract infections it is superior to intermittent self-administered antibacterial therapy.
共有21名性活跃的绝经前女性，她们易患复发性尿路感染，但在其他方面身体健康，接受了性交后预防措施，包括排空膀胱和服用一片250毫克的西诺沙星片剂。在治疗前平均7.5个月期间发生了94次尿路感染，而在预防措施实施后的平均12.5个月期间仅发生了8次。这种差异在统计学上具有高度显著性。在性交后预防期间，每位患者平均服用了106片西诺沙星片剂。西诺沙星是健康绝经前女性性交后预防复发性尿路感染的另一种有价值且有效的抗菌药物，尽管其效果略逊于复方新诺明或呋喃妥因。有效的性交后预防所需的抗菌药物用量比每日服用一片要少得多，对于复发性尿路感染发生率高的女性，它优于间歇性自我给药抗菌治疗。
