Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA, Rotterdam, The Netherlands.
Department of Biochemistry and Tissue Biology, University of Campinas, UNICAMP, Campinas, SP, 13083-862, Brazil.
Cancer Metastasis Rev. 2020 Dec;39(4):1205-1221. doi: 10.1007/s10555-020-09926-2. Epub 2020 Sep 1.
Platelets control hemostasis and play a key role in inflammation and immunity. However, platelet function may change during aging, and a role for these versatile cells in many age-related pathological processes is emerging. In addition to a well-known role in cardiovascular disease, platelet activity is now thought to contribute to cancer cell metastasis and tumor-associated venous thromboembolism (VTE) development. Worldwide, the great majority of all patients with cardiovascular disease and some with cancer receive anti-platelet therapy to reduce the risk of thrombosis. However, not only do thrombotic diseases remain a leading cause of morbidity and mortality, cancer, especially metastasis, is still the second cause of death worldwide. Understanding how platelets change during aging and how they may contribute to aging-related diseases such as cancer may contribute to steps taken along the road towards a "healthy aging" strategy. Here, we review the changes that occur in platelets during aging, and investigate how these versatile blood components contribute to cancer progression.
血小板控制止血，并在炎症和免疫中发挥关键作用。然而，血小板功能在衰老过程中可能会发生变化，这些多功能细胞在许多与年龄相关的病理过程中扮演着重要角色。除了在心血管疾病中众所周知的作用外，血小板活性现在被认为有助于癌细胞转移和与肿瘤相关的静脉血栓栓塞症（VTE）的发展。在全球范围内，绝大多数心血管疾病患者和一些癌症患者都接受抗血小板治疗以降低血栓形成的风险。然而，不仅血栓性疾病仍然是发病率和死亡率的主要原因，癌症，特别是转移，仍然是全球死亡的第二大原因。了解血小板在衰老过程中如何变化以及它们如何导致癌症等与衰老相关的疾病，可能有助于制定“健康衰老”策略。在这里，我们综述了衰老过程中血小板发生的变化，并探讨了这些多功能血液成分如何促进癌症的进展。
