Department of Gastroenterology, Peking University Third Hospital, Beijing, China.
Beijing Key Laboratory of Helicobacter pylori Infection and Upper Gastrointestinal Diseases, Peking University Third Hospital, Beijing, China.
Scand J Immunol. 2021 Feb;93(2):e12965. doi: 10.1111/sji.12965. Epub 2020 Sep 15.
CXCL17, the last described chemokine, has recently been found to be abundantly and specifically expressed in mucosal sites, while its receptor is still not well determined. Accumulative studies indicate that CXCL17 could potentially exhibit chemotactic, anti-inflammatory, antimicrobial activities under multiple biological conditions. However, the mechanism by which it contributes to the physiological and pathological processes within specific mucosal tissues is still far from being fully elucidated. In this present review, we therefore summarize the current available evidence of CXCL17 with specific emphasis on its biological role and pathophysiological significance, in order to aid in the advancement of CXCL17-related studies.
CXCL17 是最后描述的趋化因子，最近发现其在黏膜部位大量且特异性表达，但其受体仍未完全确定。累积研究表明，CXCL17 在多种生物学条件下可能表现出趋化、抗炎、抗菌活性。然而，它如何促进特定黏膜组织的生理和病理过程的机制仍远未完全阐明。因此，在本综述中，我们总结了目前关于 CXCL17 的研究证据，特别强调了其生物学作用和病理生理意义，以促进 CXCL17 相关研究的进展。
