Department of Neurology, the First Medical Centre, Chinese PLA General Hospital, PR China.
Department of Neurology, Tianjin Third Central Hospital, PR China.
Mol Pain. 2020 Jan-Dec;16:1744806920959582. doi: 10.1177/1744806920959582.
Although migraine is a major global public health problem, its impact on cognitive abilities remains controversial. Thus, the present study investigated the effects of repeated administration of inflammatory soup to the dura of rats, over three weeks, on spatial cognition, hippocampal synaptic plasticity, and the expression of N-methyl-D-aspartate receptor subunits. Additionally, low doses of amitriptyline (5 mg/kg) were applied to assess its therapeutic effects. The inflammatory soup group exhibited significant reductions in the cutaneous stimulation threshold, presence of mild cognitive impairment, and decreased long-term potentiation in right hippocampus. However, amitriptyline improved pain behaviors, enhanced cognitive function, and increased synaptic plasticity in the inflammatory soup rats. On the other hand, the administration of amitriptyline to normal rats negatively influenced synaptic plasticity and reduced the expression of N-methyl-D-aspartate receptor subunits. The present results indicate that inflammatory soup-induced dural nociception led to impairments in spatial cognition that could be attributed to reductions in hippocampal long-term potentiation and the decreased expression of N-methyl-D-aspartate receptor subunits.
虽然偏头痛是一个主要的全球公共健康问题，但它对认知能力的影响仍存在争议。因此，本研究探讨了在三周内反复向大鼠硬脑膜内注射炎症汤对空间认知、海马突触可塑性和 N-甲基-D-天冬氨酸受体亚单位表达的影响。此外，还应用了低剂量阿米替林（5mg/kg）来评估其治疗效果。炎症汤组表现出皮肤刺激阈值显著降低、轻度认知障碍存在和右侧海马长时程增强减少。然而，阿米替林改善了炎症汤大鼠的疼痛行为、认知功能和突触可塑性。另一方面，阿米替林在正常大鼠中的给药会对突触可塑性产生负面影响，并降低 N-甲基-D-天冬氨酸受体亚单位的表达。本研究结果表明，炎症汤引起的硬脑膜疼痛导致空间认知障碍，这可能归因于海马长时程增强的减少和 N-甲基-D-天冬氨酸受体亚单位表达的减少。
