Wang Qi, Zhang Guangfen, Wang Bo
Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025 Apr 28;50(4):625-630. doi: 10.11817/j.issn.1672-7347.2025.240402.
Chronic pain, a prevalent chronic disease, frequently manifests not only in physical symptoms but also in cognitive impairment, which seriously affects patients' quality of life. Interneurons are multipolar neurons, most of which are inhibitory, serving as crucial connectors within neural networks. They play key roles in signal transmission and fine-tuning of neural activity. In recent years, growing evidence has shown that interneurons are involved in the development of chronic pain and its associated cognitive dysfunction. Investigating the relationship between interneuron dysfunction and chronic pain-related cognitive impairment is of great significance, offering new potential targets and insights for the development of novel therapeutic approaches.
慢性疼痛是一种常见的慢性疾病，不仅经常表现为身体症状，还表现为认知障碍，这严重影响患者的生活质量。中间神经元是多极神经元，其中大多数是抑制性的，是神经网络中的关键连接者。它们在神经活动的信号传递和微调中起关键作用。近年来，越来越多的证据表明，中间神经元参与慢性疼痛的发展及其相关的认知功能障碍。研究中间神经元功能障碍与慢性疼痛相关认知障碍之间的关系具有重要意义，为开发新的治疗方法提供了新的潜在靶点和思路。
