可见光诱导三催化的环丙基酮开环氰化反应。
Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones.
机构信息
CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
Chem Commun (Camb). 2020 Sep 29;56(77):11508-11511. doi: 10.1039/d0cc05167e.
PMID:32869792
Abstract
An unprecedented triple catalytic, general ring-opening cyanation reaction of cyclopropyl ketones for the construction of γ-cyanoketones is described. The key is to merge photoredox catalysis with Lewis acid catalysis and copper catalysis to enable the selective cleavage of the carbon-carbon bonds and the selective coupling of the generated radical and cyanide anion.
摘要
本文描述了一种前所未有的三催化、环丙酮的普遍开环氰化反应，用于构建γ-氰基酮。关键是将光氧化还原催化与路易斯酸催化和铜催化融合，以实现碳-碳键的选择性断裂以及生成的自由基和氰阴离子的选择性偶联。
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