Department of Dermatology and Venereology, Ufuk University Hospital, Ankara, Turkey.
Clin Exp Dermatol. 2021 Mar;46(2):286-291. doi: 10.1111/ced.14432. Epub 2020 Oct 10.
Behçet disease (BD) is an immune-mediated vasculitis-like syndrome characterized by recurrent aphthous lesions and various systemic manifestations. Inflammatory markers may be useful to assess disease severity. The Systemic Immune-Inflammation Index (SII) (neutrophils × platelets/lymphocytes) has been widely used in oncology since 2014, with promising results.
To assess the efficiency of the SII in determining activity of BD.
This retrospective cohort study was conducted on patients with BD who were admitted to the outpatient clinic of the Department of Dermatology and Venereology, Ufuk University Hospital, between 1 January 2010 and 31 December 2019. Patients were divided into two groups based on their disease status upon admission: (i) active BD (n = 103), and (ii) inactive BD (n = 63). Clinical characteristics, demographic features, type of medications, full blood count parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin and SII were compared between the groups. Furthermore, receiver operating characteristic curve analysis was performed to assess the performance of the SII in determining disease severity upon admission to hospital.
Higher numbers of white blood cells, platelets and neutrophils, greater red cell distribution width, higher levels of ESR, CRP and ferritin, and higher SII were observed in the active disease group (P < 0.001). The cutoff value of 552 × 10 /mm was found to have 81% sensitivity and 82% specificity.
The SII may be used as an additional indicator for the assessment of BD status and physicians should be cautious in patients with SII levels of > 552 × 10 /mm ) at the initial evaluation of the patients.
白塞病（BD）是一种免疫介导的血管炎样综合征，其特征为复发性口腔溃疡和各种全身表现。炎症标志物可用于评估疾病严重程度。自 2014 年以来，全身性免疫炎症指数（SII）（中性粒细胞×血小板/淋巴细胞）已在肿瘤学中广泛应用，取得了良好的效果。
评估 SII 在确定 BD 活动度中的效率。
这项回顾性队列研究纳入了 2010 年 1 月 1 日至 2019 年 12 月 31 日期间在乌弗克大学医院皮肤科和性病科门诊就诊的 BD 患者。根据入院时的疾病状况将患者分为两组：（i）活动期 BD（n=103），和（ii）非活动期 BD（n=63）。比较两组间的临床特征、人口统计学特征、药物类型、全血细胞计数参数、红细胞沉降率（ESR）、C 反应蛋白（CRP）、铁蛋白和 SII。此外，还进行了受试者工作特征曲线分析，以评估 SII 在入院时确定疾病严重程度的性能。
活动期疾病组的白细胞、血小板和中性粒细胞数量更高，红细胞分布宽度更大，ESR、CRP 和铁蛋白水平更高，SII 更高（P<0.001）。发现 SII 的截断值为 552×10 /mm 时，具有 81%的敏感性和 82%的特异性。
SII 可作为评估 BD 状态的附加指标，医生在评估患者时应谨慎，对于 SII 水平>552×10 /mm 的患者。
