NMR Signal Enhancement Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Center for Biostructural Imaging of Neurodegeneration of UMG, Göttingen, Germany.
NMR Biomed. 2021 Jan;34(1):e4400. doi: 10.1002/nbm.4400. Epub 2020 Sep 1.
MR is a prominent technology to investigate diseases, with millions of clinical procedures performed every year. Metabolic dysfunction is one common aspect associated with many diseases. Thus, understanding and monitoring metabolic changes is essential to develop cures for many illnesses, including for example cancer and neurodegeneration. MR methodologies are especially suited to study endogenous metabolites and processes within an organism in vivo, which has led to many insights about physiological functions. Advancing metabolic MR techniques is therefore key to further understand physiological processes. Here, we introduce an approach based on nuclear spin singlet states to specifically filter metabolic signals and particularly show that singlet-filtered glutamate can be observed distinctly in the hippocampus of a living mouse in vivo. This development opens opportunities to make use of the singlet spin phenomenon in vivo and besides its use as a filter to provide scope for new contrast agents.
磁共振（MR）是一种研究疾病的重要技术，每年都有数百万例临床操作。代谢功能障碍是与许多疾病相关的一个常见方面。因此，了解和监测代谢变化对于开发许多疾病的治疗方法至关重要，例如癌症和神经退行性疾病。MR 方法特别适合研究生物体体内的内源性代谢物和过程，这为生理功能提供了许多见解。因此，推进代谢磁共振技术是进一步了解生理过程的关键。在这里，我们介绍了一种基于核自旋单态的方法，该方法可以专门筛选代谢信号，特别是可以在活体小鼠的海马体中明显观察到单态过滤谷氨酸。这一发展为在体内利用单态自旋现象提供了机会，并且除了用作滤波器外，还为新的对比剂提供了应用前景。
