Androscience, Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Research Laboratory, São Paulo, Brazil.
Division of Urology, University of São Paulo, São Paulo, Brazil.
Andrology. 2021 Jan;9(1):73-79. doi: 10.1111/andr.12896. Epub 2020 Sep 30.
The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, named coronavirus disease 19 (COVID-19), is not the first well-known spillover of an animal originated virus to infect humans. However, one of the few to make such a fast jump in a powerful evolutionary shortcut. The incredible pattern of aggressiveness worldwide since the beginning of the outbreak is that up to 20% of those infected need hospitalization and 5% evolve to critical conditions, not limited to respiratory-related issues, but rather to systemic involvement.
This study aims to summarize the current knowledge about the effects of SARS-CoV-2 infection on the male genitourinary tract.
A narrative review was carried out to identify articles on the SARS-CoV-2 infection on the male genitourinary system.
Considerations were made about the molecular characteristics of SARS-CoV-2 and immune response to coronavirus. We discussed the influence of the virus on the urinary system, potential mechanisms of COVID-19- related acute kidney injury (AKI), and the role of cytokine release syndrome on the renal pathophysiology of the disease. In the male reproductive tract, it was discussed the testis' vulnerability to SARS-CoV-2 invasion and the possible adverse effects on its function and the seminal findings of COVID-19.
During the COVID-19 pandemic, an international coordinated scientific effort must arise to understand the role of the urogenital system in the SARS-CoV-2 infection in the clinical setting.
目前严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染的爆发，被命名为 2019 冠状病毒病（COVID-19），并不是第一个众所周知的由动物起源的病毒感染人类的例子。然而，它是少数几个能够通过强大的进化捷径快速跳跃的病毒之一。自疫情爆发以来，全球范围内令人难以置信的攻击性模式是，高达 20%的感染者需要住院治疗，5%的感染者病情发展为危急状况，不仅限于与呼吸系统相关的问题，而是全身性的。
本研究旨在总结目前关于 SARS-CoV-2 感染对男性生殖泌尿系统影响的知识。
进行了叙述性综述，以确定有关 SARS-CoV-2 感染男性泌尿系统的文章。
考虑了 SARS-CoV-2 的分子特征和对冠状病毒的免疫反应。我们讨论了病毒对泌尿系统的影响、COVID-19 相关急性肾损伤（AKI）的潜在机制，以及细胞因子释放综合征在疾病的肾脏病理生理学中的作用。在男性生殖系统中，讨论了睾丸对 SARS-CoV-2 入侵的易感性及其对其功能的可能不利影响，以及 COVID-19 的精液发现。
在 COVID-19 大流行期间，必须在国际上协调科学努力，以了解泌尿生殖系统在 SARS-CoV-2 感染中的作用。
