Wilker D, Sklarek J, Waldner H, Posel P
Chirurgische Klinik Innenstadt der LMU München.
Langenbecks Arch Chir. 1988;373(2):91-6. doi: 10.1007/BF01262770.
Healing of intestinal anastomoses was found to be effective in rat, rabbit and pig even after temporary approximation by sutures for one hour. Approximation of bowel segments was achieved by interrupted inverting sutures. After one hour a fibrinous connection of inverted serosa segments was to be observed. Bursting pressure was determined on the 1st, 3rd and 7th postoperative day. There was no significant difference between sutureless and regular anastomoses. Determination of breaking strength of approximated anastomoses one hour and twenty-four hours after removal of sutures was found to be 0.19 N and 0.8 N, respectively. Extent of adhesions was similar in conventional and sutureless anastomoses. Histologic analyses revealed areas of necrosis in sutured anastomoses, whereas in sutureless anastomoses no necrosis could be detected.
研究发现，即使在通过缝合暂时吻合一小时后，大鼠、兔子和猪的肠吻合口愈合效果依然良好。肠段的吻合通过间断内翻缝合实现。一小时后可观察到倒置浆膜段的纤维性连接。在术后第1天、第3天和第7天测定破裂压力。无缝合吻合与常规吻合之间无显著差异。发现去除缝线后一小时和二十四小时，近似吻合口的断裂强度分别为0.19 N和0.8 N。传统吻合和无缝合吻合的粘连程度相似。组织学分析显示，缝合吻合口有坏死区域，而无缝合吻合口中未检测到坏死。
