Jönsson K, Jiborn H, Zederfeldt B
Am J Surg. 1983 Jun;145(6):800-3. doi: 10.1016/0002-9610(83)90144-7.
The breaking strength of standardized small bowel anastomoses at different times after surgery was studied in the rat. The anastomotic strength with sutures in place successively decreased during the first 3 postoperative days to approximately 15 percent of the immediate postoperative value. This indicates a rapid decrease in the suture holding capacity of the gut wall in the early postoperative course. From the fourth day onward a rapid increase in strength was recorded. This could be due not only to deposition of collagen in the tissue bridging the anastomosis but also to the regained capacity of the gut wall to withstand tearing forces. After 14 days the strength of the anastomosis was due mainly to healing, and the relative contribution from the sutures was negligible. It may be that tearing of sutures through the tissue is more important than defective healing for anastomotic complications.
在大鼠身上研究了手术后不同时间标准化小肠吻合口的抗张强度。术后前3天，带缝线的吻合口强度持续下降，降至术后即刻值的约15%。这表明术后早期肠壁的缝线夹持能力迅速下降。从第4天起，强度迅速增加。这可能不仅是由于吻合口桥接组织中胶原蛋白的沉积，还由于肠壁恢复了承受撕裂力的能力。14天后，吻合口的强度主要归因于愈合，缝线的相对作用可忽略不计。对于吻合口并发症来说，缝线穿过组织的撕裂可能比愈合缺陷更重要。
