Shenzhen Kangning Hospital, Shenzhen Mental Health Center; Shenzhen University, Mental Health School, Shenzhen 518020, China.
Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080.
J Affect Disord. 2020 Nov 1;276:546-554. doi: 10.1016/j.jad.2020.07.001. Epub 2020 Jul 15.
Childhood trauma is associated with major depressive disorder (MDD) and bipolar disorder (BD) in adults. However, no meta-analysis was performed on the prevalence of different types of childhood trauma in adults with affective disorders, using the Childhood Trauma Questionnaire (CTQ).
Four databases were used to search articles regarding the prevalence of childhood emotional abuse (CEA), childhood physical abuse (CPA), childhood sexual abuse (CSA), childhood physical neglect (CPN), and childhood emotional neglect (CEN) in patients with MDD and BD using the CTQ.
A total of 17 and 11 articles were found analyzing patients with MDD and BD, respectively. A pooled prevalence rate of 33.0% and 30.0% for CEA, 17.0% and 18.0% for CPA, 19.0% and 22.0% for CSA, 37.0% and 31.0% for CEN, and 31% and 30.0% for CPN was found in patients with MDD and BD respectively. A difference in 95% confidence interval in the CSA rate between men and women was found in patients with MDD in the gender subgroup and in the rate of some types of childhood trauma in the continent subgroup in both patient types.
A limited number of articles were included in some continents, thus, the heterogeneity in the meta-analysis was generally high.
The prevalence of CEA, CEN, and CPN in patients with affective disorders was relatively high, whereas that of CPA and CSA was relatively low. These childhood traumas might be affected by continent and gender.
儿童期创伤与成年期的重性抑郁障碍（MDD）和双相障碍（BD）有关。然而，尚未使用儿童期创伤问卷（CTQ）对情感障碍成年患者中不同类型儿童期创伤的患病率进行荟萃分析。
使用 CTQ 对 MDD 和 BD 患者的儿童期情绪虐待（CEA）、儿童期躯体虐待（CPA）、儿童期性虐待（CSA）、儿童期躯体忽视（CPN）和儿童期情感忽视（CEN）的患病率进行了 4 个数据库的文献检索。
共发现分析 MDD 和 BD 患者的 17 篇和 11 篇文章。MDD 和 BD 患者的 CEA 总患病率分别为 33.0%和 30.0%，CPA 分别为 17.0%和 18.0%，CSA 分别为 19.0%和 22.0%，CEN 分别为 37.0%和 31.0%，CPN 分别为 31%和 30.0%。在 MDD 患者的性别亚组中发现 CSA 率的 95%置信区间存在差异，在两种患者类型的大陆亚组中发现某些类型的儿童期创伤率存在差异。
一些大陆的文章数量有限，因此荟萃分析的异质性通常较高。
情感障碍患者的 CEA、CEN 和 CPN 患病率较高，而 CPA 和 CSA 患病率较低。这些儿童创伤可能受大陆和性别影响。
