The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
The National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China.
Child Abuse Negl. 2023 Jul;141:106203. doi: 10.1016/j.chiabu.2023.106203. Epub 2023 Apr 21.
Childhood trauma is an environmental risk factor for bipolar disorder (BD), But its influence on the clinical features of BD has not been examined sufficiently.
We compared the childhood trauma between patients with BD and healthy controls (HCs) and determined how childhood trauma impacts clinical features, such as severity, mood episodes, and disease duration.
The study population comprised patients with BD (in a state of euthymia or depression, n = 90) and HCs (n = 94).
The Structured Clinical Interview for DSM-IV Axis I Disorders was used to diagnose BD and ascertain its clinical features. The Childhood Trauma Questionnaire (CTQ) was used to assess childhood trauma.
The total CTQ score and scores for the CTQ subscales emotional abuse, sexual abuse, emotional neglect, and physical neglect, significantly differed between the BD and HC groups. Emotional abuse was correlated with higher Hamilton Anxiety Rating Scale (HARS) score and more frequent mood episodes; emotional neglect was correlated with higher HARS score, longer disease duration, and more mood episodes; and total CTQ score was positively correlated with HARS score, disease duration, and mood episodes. Regression analysis showed that emotional neglect significantly predicted HARS score, Hamilton Depression Rating Scale score, and disease duration in the BD group (P < 0.05).
Patients with BD have more serious childhood trauma. General childhood trauma, emotional abuse, and emotional neglect negatively affect the clinical features of BD.
童年创伤是双相情感障碍（BD）的环境风险因素，但它对 BD 的临床特征的影响尚未得到充分研究。
我们比较了 BD 患者和健康对照者（HCs）之间的童年创伤，并确定了童年创伤如何影响临床特征，如严重程度、情绪发作和疾病持续时间。
研究人群包括处于缓解期或抑郁期的 BD 患者（n=90）和 HCs（n=94）。
使用DSM-IV 轴 I 障碍的结构临床访谈来诊断 BD 并确定其临床特征。使用童年创伤问卷（CTQ）评估童年创伤。
BD 和 HCs 组之间的 CTQ 总分和 CTQ 子量表（情感虐待、性虐待、情感忽视和身体忽视）得分存在显著差异。情感虐待与更高的汉密尔顿焦虑量表（HARS）评分和更频繁的情绪发作相关；情感忽视与更高的 HARS 评分、更长的疾病持续时间和更多的情绪发作相关；总 CTQ 评分与 HARS 评分、疾病持续时间和情绪发作呈正相关。回归分析显示，情感忽视显著预测了 BD 组的 HARS 评分、汉密尔顿抑郁量表评分和疾病持续时间（P<0.05）。
BD 患者有更严重的童年创伤。一般的童年创伤、情感虐待和情感忽视对 BD 的临床特征有负面影响。
