Department of Medical Oncology, Limoges University Hospital, Limoges, France.
Department of Radiology, Limoges University Hospital, Limoges, France.
In Vivo. 2020 Sep-Oct;34(5):2873-2881. doi: 10.21873/invivo.12115.
BACKGROUND/AIM: To investigate the impact of body composition on morbidity and mortality at the initial diagnosis of localised renal cell carcinoma (RCC) in patients with overweight or obesity.
Sarcopenia was defined using sex-specific cut-off points and other body composition parameters by median values with computed tomography imaging.
Among the 96 patients, 40 had sarcopenia (43.0%) at diagnosis. Body composition had no effect on morbidity and 5-year disease-free survival contrary to the classic factors (p<0.05). In the subgroup of obese patients, those with sarcopenia had a poor prognosis (p=0.04) but not in the population with overweight (p=0.9).
Sarcopenia was frequently associated with localised RCC at the initial diagnosis. Body composition did not affect morbidity or outcomes. BMI was involved in morbidity and there was paradoxically longer survival in the obesity group.
背景/目的：研究超重或肥胖的局限性肾细胞癌（RCC）患者在初始诊断时，身体成分对发病率和死亡率的影响。
使用 CT 成像的性别特异性截断值和中位数定义肌少症和其他身体成分参数。
在 96 名患者中，40 名患者在诊断时患有肌少症（43.0%）。与经典因素（p<0.05）相反，身体成分对发病率和 5 年无病生存率没有影响。在肥胖患者亚组中，肌少症患者预后不良（p=0.04），但在超重人群中并非如此（p=0.9）。
肌少症常与局限性 RCC 初诊相关。身体成分并不影响发病率或结局。BMI 与发病率有关，而在肥胖组中却存在更长的生存时间。
