Tan Chin-Chieh, Sheng Ting-Wen, Chang Ying-Hsu, Wang Li-Jen, Chuang Cheng-Keng, Wu Chun-Te, Pang See-Tong, Shao I-Hung
Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Department of Medical Imaging and Intervention, New Taipei Municipal Tu Cheng Hospital, Chang Gung Memorial Hospital, Chang Gung University, New Taipei City 236, Taiwan.
J Clin Med. 2022 Jul 30;11(15):4444. doi: 10.3390/jcm11154444.
This study aimed to elucidate the change of body composition in different clinical stages of renal cell carcinoma (RCC) by analyzing computed tomography (CT) images.
We enrolled patients diagnosed with RCC in a tertiary medical center who did not mention body weight loss or symptoms of cachexia. We grouped patients into those with localized RCC and those with metastatic RCC. Analyses of the volume of skeletal muscles tissue (SMT), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) calculated based on CT images were performed and included subgroup analyses by sex and age. The correlation between tumor size and body composition in localized RCC was also examined.
A total of 188 patients were enrolled in this study. There was significantly lower VAT ( = 0.015) in the metastatic group than in the localized group. SAT, body weight, and body mass index (BMI) were not significantly different between these two groups. In the subgroup analysis, a significant difference in SMT and VAT was noted in the male and younger subgroups but not in the female and older subgroups. Regarding primary tumor size in localized RCC, VAT was significantly higher in patients with larger tumors ( = 0.003).
In localized RCC, VAT volume was significantly larger in those with large primary tumor size. However, the VAT was significantly lower in those with metastatic status comparing to those with localized disease. The clinical course of cancers closely correlates with body composition.
本研究旨在通过分析计算机断层扫描（CT）图像来阐明肾细胞癌（RCC）不同临床阶段身体成分的变化。
我们纳入了一家三级医疗中心诊断为RCC且未提及体重减轻或恶病质症状的患者。我们将患者分为局限性RCC患者和转移性RCC患者。对基于CT图像计算的骨骼肌组织（SMT）、皮下脂肪组织（SAT）和内脏脂肪组织（VAT）的体积进行分析，并包括按性别和年龄的亚组分析。还研究了局限性RCC中肿瘤大小与身体成分之间的相关性。
本研究共纳入188例患者。转移组的VAT显著低于局限性组（=0.015）。这两组之间的SAT、体重和体重指数（BMI）无显著差异。在亚组分析中，男性和年轻亚组的SMT和VAT有显著差异，而女性和老年亚组则无。关于局限性RCC的原发肿瘤大小，肿瘤较大的患者VAT显著更高（=0.003）。
在局限性RCC中，原发肿瘤较大者的VAT体积显著更大。然而，与局限性疾病患者相比，转移状态患者的VAT显著更低。癌症的临床病程与身体成分密切相关。
