Liu Nanyang, Zhang Tingting, Ma Lina, Wang Huican, Li Hao
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing.
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, P.R. China.
Medicine (Baltimore). 2020 Aug 14;99(33):e21709. doi: 10.1097/MD.0000000000021709.
The 2019 Coronavirus Disease (COVID-19) pandemic has threatened millions of people worldwide. Growing evidence suggests that the ABO blood type contributed to the susceptibility of COVID-19, but the results are controversial. The major objective of this systematic review and meta-analysis study is to investigate the impact of ABO blood group on COVID-19 pneumonia.
Two independent reviewers searches the databases of the China Biology Medicine disc, China National Knowledge Infrastructure, China Science and Technology Periodical Database, Wanfang Database, PubMed, Embase, and Web of Science from the date of conception to June 30, 2020. We will manually search for gray literature, such as meeting records and dissertations. Two independent reviewers will screen studies that meet the criteria, extract data, statistical data, and assess the risk of bias. The dichotomous variable will calculate the odds ratio and the corresponding 95% confidence interval. Heterogeneity between included studies will be assessed by heterogeneity χ tests and I index. The forest plots will be used to describe the pooled results. The Begg rank correlation test or Egger linear regression test will be performed to quantize the publication bias.
This study will provide high-quality evidence to evaluate the contribution of the ABO blood group in COVID-19 pneumonia infection.
CRD42020195615.
2019年冠状病毒病（COVID-19）大流行已威胁到全球数百万人。越来越多的证据表明，ABO血型与COVID-19的易感性有关，但结果存在争议。本系统评价和荟萃分析研究的主要目的是调查ABO血型对COVID-19肺炎的影响。
两名独立评审员检索中国生物医学文献数据库、中国知网、维普数据库、万方数据库、PubMed、Embase和Web of Science等数据库，检索时间从概念形成之日至2020年6月30日。我们将手动检索灰色文献，如会议记录和学位论文。两名独立评审员将筛选符合标准的研究，提取数据、统计数据，并评估偏倚风险。二分变量将计算比值比及相应的95%置信区间。纳入研究之间的异质性将通过异质性χ检验和I指数进行评估。森林图将用于描述汇总结果。将进行Begg秩相关检验或Egger线性回归检验以量化发表偏倚。
本研究将为评估ABO血型在COVID-19肺炎感染中的作用提供高质量证据。
PROSPERO注册号：CRD42020195615。
