Chappell L H
Department of Zoology, University of Aberdeen, Scotland.
Parasitology. 1988;96 Suppl:S167-93. doi: 10.1017/s0031182000086029.
The interrelationships between drugs and parasite surfaces are considered under the headings of (a) effects on membrane transport, (b) drug uptake mechanisms and (c) effects on surface morphology and function: praziquantel is discussed under a separate heading. The range of chemotherapeutic compounds that cause permeability changes and concomitant morphological disruption is discussed in terms of mode of drug action. Interpretation of the available data renders it difficult to identify the primary mode of action in the drugs considered. Drug uptake mechanisms are known for relatively few compounds; drug resistance as a function of drug acquisition is discussed. The role of the parasite surface as a specific drug target is argued.
(a) 对膜转运的影响；(b) 药物摄取机制；(c) 对表面形态和功能的影响：吡喹酮将在单独的标题下进行讨论。根据药物作用方式，讨论了导致通透性变化和随之而来的形态破坏的一系列化疗化合物。对现有数据的解读使得难以确定所考虑药物的主要作用方式。已知相对较少化合物的药物摄取机制；讨论了作为药物摄取函数的耐药性。论证了寄生虫表面作为特定药物靶点的作用。
