He Mingqian, Li Yuan, Zhu Dashuai, Li Junlang, Cangu Meggie, Tasoudis Panagiotis, Xu Jiazhu, Caranasos Thomas G, Hong Yi, Huang Ke
Department of Biomedical Engineering, University of North Carolina Chapel Hill and NC State University, North Carolina, USA.
Department of Biomedical Engineering, Columbia University, New York, USA.
Bioact Mater. 2025 Jul 7;53:45-57. doi: 10.1016/j.bioactmat.2025.06.055. eCollection 2025 Nov.
Myocardial infarction (MI), commonly known as a heart attack, remains a leading cause of death worldwide. Standard treatments, such as coronary stent placement or coronary artery bypass graft surgery, aim to restore blood flow to ischemic myocardial tissue. However, a significant complication of these procedures is ischemia/reperfusion (I/R) injury, which occurs when blood flow is restored, triggering oxidative stress, inflammation, and calcium overload that can further damage the heart. To limit the I/R injury following the coronary recanalization of an MI heart, we designed stromal-platelet membrane-inspired nanoparticles (SPINs) that consist of a poly (lactic-co-glycolic acid) (PLGA) core, decorated by a dual membrane coating: a platelet membrane for precise adhesion to the damaged endothelium area and a stromal cell membrane to enhance receptor-ligand interactions and immune-evasiveness. This unique dual-membrane configuration synergistically reduces fibrosis and inflammation while promoting angiomyogenesis. This combination integrates the vascular injury targeting and immune-evasive properties of the nanoparticle, making this dual-membrane design a promising add-on intervention to augment post- percutaneous coronary intervention recovery, enhancing outcomes and offering potential improved cardiac repair.
心肌梗死（MI），通常称为心脏病发作，仍然是全球主要的死亡原因。标准治疗方法，如冠状动脉支架置入术或冠状动脉旁路移植手术，旨在恢复缺血心肌组织的血流。然而，这些手术的一个重大并发症是缺血/再灌注（I/R）损伤，当血流恢复时就会发生，引发氧化应激、炎症和钙超载，进而可能进一步损害心脏。为了限制心肌梗死心脏冠状动脉再通后的I/R损伤，我们设计了受基质-血小板膜启发的纳米颗粒（SPINs），其由聚（乳酸-乙醇酸）（PLGA）核心组成，并由双膜涂层修饰：一种血小板膜用于精确粘附到受损的内皮区域，一种基质细胞膜用于增强受体-配体相互作用和免疫逃避。这种独特的双膜结构协同减少纤维化和炎症，同时促进血管生成。这种组合整合了纳米颗粒的血管损伤靶向和免疫逃避特性，使这种双膜设计成为一种有前景的附加干预措施，以增强经皮冠状动脉介入治疗后的恢复，改善治疗结果并提供潜在的更好的心脏修复效果。
