使用抗精神病药物治疗的精神分裂症患者代谢综合征的患病率。
Prevalence of metabolic syndrome in schizophrenia patients treated with antipsychotic medications.
作者信息
Jaberi Nayyer, Faramarzi Elnaz, Farahbakhsh Mostafa, Ostadarahimi Alireza, Asghari Jafarabadi Mohammad, Fakhari Ali
机构信息
Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical sciences, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research center, Tabriz University of Medical sciences, Tabriz, Iran.
出版信息
Caspian J Intern Med. 2020 May;11(3):310-314. doi: 10.22088/cjim.11.3.310.
BACKGROUND
This study was conducted to determine the prevalence of metabolic syndrome (Mets) in schizophrenic patients in a 6-month period of treatment with antipsychotic medications.
METHODS
In this study, 60 volunteer schizophrenic patients were included. At the onset and 6 months after treatment with antipsychotic medications, fasting blood sugar (FBS), serum triglyceride (TG), high density lipoprotein (HDL), weight, waist circumference (WC), and blood pressure were determined. We defined Mets according to ATPIII criteria.
RESULTS
After a 6-month treatment with antipsychotic drugs, the mean WC, serum TG, HDL, systolic and diastolic blood pressure increased but the changes of WC and HDL were statistically significant (p<0.05). We found that the percentage of patients with high WC, low HDL levels, and Mets increased after treatment which was statistically significant (p<0.05).
CONCLUSION
It is recommended that nutritional and lifestyle changes intervention should be implanted for schizophrenic patients undergoing treatment.
背景
本研究旨在确定精神分裂症患者在接受抗精神病药物治疗6个月期间代谢综合征（Mets）的患病率。
方法
本研究纳入了60名自愿参与的精神分裂症患者。在开始使用抗精神病药物治疗时以及治疗6个月后，测定空腹血糖（FBS）、血清甘油三酯（TG）、高密度脂蛋白（HDL）、体重、腰围（WC）和血压。我们根据ATPIII标准定义Mets。
结果
经过6个月的抗精神病药物治疗后，平均WC、血清TG、HDL、收缩压和舒张压均升高，但WC和HDL的变化具有统计学意义（p<0.05）。我们发现治疗后WC高、HDL水平低和患有Mets的患者百分比增加，且具有统计学意义（p<0.05）。
结论
建议对正在接受治疗的精神分裂症患者实施营养和生活方式改变干预。
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