Ding Mubing, Zhang Shaotong, Zhu Zaochen, Cai Renliang, Fang Jin, Zhou Chao, Zhang Xiangrong, Fang Xinyu
Department of Psychiatry, Beijing Anding Hospital Affiliated to Capital Medical University Wuhu Hospital & Wuhu Fourth People's Hospital, Wuhu, China.
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Front Psychiatry. 2024 Jul 18;15:1436142. doi: 10.3389/fpsyt.2024.1436142. eCollection 2024.
The aim of this study was to explore the risk factors for different metabolic status in patients with schizophrenia.
A total of 968 hospitalized patients with schizophrenia were recruited. Fasting blood glucose (GLU) and lipid profile, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were measured. Schizophrenia patients were divided into four groups: normal metabolism and weight (NMNW), abnormal metabolism and normal weight (AMNW), normal metabolism and overweight/obesity (NMO), and abnormal metabolism and overweight/obesity (AMO).
Our results showed that NMNW, AMNW, NMO, and AMO accounted for 25.3%, 12.7%, 25.4%, and 36.6%, respectively. There were significant differences in age, disease duration, body mass index (BMI), waist circumference, chronic disease, systolic blood pressure (SBP), diastolic blood pressure (DBP), GLU, TG, TC, HDL-C, and LDL-C among these four groups (all p < 0.05). With the NMNW group as the reference, the disordered multiple classification regression analysis showed that chronic disease was a significant risk factor for AMNW (OR = 5.271, 95% CI = 3.165 to 8.780, p < 0.001) and AMO (OR = 3.245, 95% CI = 2.004 to 5.254, p < 0.001), age was an important protective factor for NMO (OR = 0.968, 95% CI = 0.943 to 0.994, p = 0.015) and AMO (OR = 0.973, 95% CI = 0.948 to 0.999, p < 0.042), waist circumference was a significant risk factor for NMO (OR = 1.218, 95% CI = 1.180 to 1.257, p < 0.001) and AMO (OR = 1.252, 95% CI = 1.212 to 1.291, p < 0.001), and college education was an obvious protective factor for AMO (OR = 0.343, 95% CI = 0.123 to 0.953, p < 0.040) among patients with schizophrenia.
The findings of our study underscored the importance of factors such as age, education level, chronic disease, and waist circumference when exploring the influencing factors and biological mechanisms of obesity-related metabolic problems in schizophrenia patients.
本研究旨在探讨精神分裂症患者不同代谢状态的危险因素。
共招募了968例住院精神分裂症患者。测量空腹血糖（GLU）和血脂谱，包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）。精神分裂症患者被分为四组：代谢和体重正常（NMNW）、代谢异常但体重正常（AMNW）、代谢正常但超重/肥胖（NMO）以及代谢异常且超重/肥胖（AMO）。
我们的结果显示，NMNW、AMNW、NMO和AMO分别占25.3%、12.7%、25.4%和36.6%。这四组在年龄、病程、体重指数（BMI）、腰围、慢性病、收缩压（SBP）、舒张压（DBP）、GLU、TG、TC、HDL-C和LDL-C方面存在显著差异（均p<0.05）。以NMNW组为参照，无序多分类回归分析显示，慢性病是AMNW（OR = 5.271，95%CI = 3.165至8.780，p<0.001）和AMO（OR = 3.245，95%CI = 2.004至5.254，p<0.001）的显著危险因素，年龄是NMO（OR = 0.968，95%CI = 0.943至0.994，p = 0.015）和AMO（OR = 0.973，95%CI = 0.948至0.999，p<0.042）的重要保护因素，腰围是NMO（OR = 1.218，95%CI = 1.180至1.257，p<0.
