Department of Internal Medicine, Faculty of Medicine, University of Jordan, Queen Rania Street, Amman, Jordan.
Department of Psychology, Faculty of Nursing, University of Jordan, Queen Rania Street, Amman, Jordan.
Endocr Metab Immune Disord Drug Targets. 2021;21(6):1107-1114. doi: 10.2174/1871530320999200831230205.
Compared to the data available for developed countries, there is a marked scarcity of information on the levels and symptomology of vitamin B deficiency in developing countries, particularly in the Middle Eastern region.
To explore (a) the risk factors associated with a deficiency of vitamin B, and (b) the baseline (cut-off) serum level of vitamin B for a clinically-symptomatic deficiency in the Jordanian adult population.
A total of 485 subjects were included in this study. Blood samples were drawn for biochemical analysis and data regarding socio-demographics, general health, anthropometric measures, and past medical, surgical, and medication history were collected. To explore the cut-off point, we compared all parameters included in a standard complete blood count as well as the main symptoms reported to be associated with B deficiency between groups of different B cut-off values, consisting of those above and below 200, 175, 150 and 125 pg/ml.
Low dairy intake habits, age, recurrent headaches, heartburn, and peptic ulcer disease were found to be significantly associated with lower vitamin B levels. Surprisingly, daily smoking was associated with significantly higher B levels. The results revealed that none of the included potential indicators of B deficiency could be considered an indicative feature of deficiency. There were no significant differences neither in the symptoms nor in the CBC parameters between any of the tested study groups.
Low dairy intake, older ages, recurrent headaches, heartburn, and peptic ulcer disease all could be considered as risk factors of having low vitamin B levels within the Jordanians. Also, they tend to have lower levels of vitamin B levels, in comparison to countries in the West, without necessarily having deficiency symptoms. The cut-off value to diagnose functional B deficiency could be less than 125 pg/ml for the Jordanians. More local studies are needed to establish an accurate vitamin B cut-off value for the population in Jordan.
与发达国家的数据相比，发展中国家，特别是中东地区，关于维生素 B 缺乏症的水平和症状的数据明显匮乏。
探讨（a）与维生素 B 缺乏相关的风险因素，以及（b）在约旦成年人群中，维生素 B 缺乏症的临床症状的基线（临界值）血清水平。
本研究共纳入 485 名受试者。采集血样进行生化分析，并收集社会人口统计学、一般健康、人体测量学指标以及过去的医疗、手术和用药史等数据。为了探索临界值，我们比较了不同 B 临界值组（包括高于和低于 200、175、150 和 125 pg/ml 的组）之间的全血细胞计数中的所有参数以及与 B 缺乏相关的主要症状。
低乳制品摄入量、年龄、反复头痛、烧心和消化性溃疡病与维生素 B 水平较低显著相关。令人惊讶的是，每日吸烟与 B 水平显著升高相关。结果表明，纳入的任何潜在的 B 缺乏指标都不能被认为是缺乏的特征。在任何测试的研究组之间，都没有发现症状或 CBC 参数有显著差异。
低乳制品摄入量、年龄较大、反复头痛、烧心和消化性溃疡病都可能被认为是约旦人维生素 B 水平较低的危险因素。此外，与西方国家相比，他们的维生素 B 水平较低，但不一定有缺乏症状。诊断功能性 B 缺乏的临界值可能低于 125 pg/ml。需要更多的本地研究来为约旦人口建立准确的维生素 B 临界值。
