Otto D, Hudnell K, Boyes W, Janssen R, Dyer R
Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Toxicology. 1988 May;49(2-3):205-18. doi: 10.1016/0300-483x(88)90001-7.
The application of auditory and visual evoked potentials (VEP) to neurotoxicity testing of humans and animals is reviewed. VEPs elicited by flash, reversing-checkerboard patterns, and sine wave grating are described. The flask evoked potential in rats is altered by exposure to many heavy metals, pesticides and solvents. The brainstem auditory evoked potential also appears to be sensitive to neurotoxic chemicals, but the evidence available is limited. The homology of auditory and visual evoked potentials in rats and humans is useful for cross-species extrapolation in neurotoxicology research.
综述了听觉和视觉诱发电位（VEP）在人类和动物神经毒性测试中的应用。描述了由闪光、反转棋盘图案和正弦波光栅诱发的VEP。大鼠的闪光诱发电位会因接触多种重金属、农药和溶剂而改变。脑干听觉诱发电位似乎也对神经毒性化学物质敏感，但现有证据有限。大鼠和人类听觉与视觉诱发电位的同源性在神经毒理学研究的跨物种推断中很有用。
