Dyer R S, Burdette L J, Janssen R, Boyes W K
Fundam Appl Toxicol. 1985 Oct;5(5):920-32. doi: 10.1016/0272-0590(85)90174-5.
A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3-, or 4-methylpyridine at dosages of 100 mg/kg, approximately one-half the ip LD50. The tests contained measures of sensory function (paired pulse flash evoked potentials, pattern reversal evoked potentials, and brainstem auditory evoked responses) and cerebral excitability (pentylenetetrazol seizures and hippocampal afterdischarges). In general, rats treated with 2- and 3-methylpyridine were more affected than those treated with 4-methylpyridine. The changes observed were in many ways similar to those seen following administration of depressant compounds: increased latency of evoked potentials and increased latency to PTZ seizures. Not all findings, however, were consistent with previously observed patterns of central nervous system depression.
对Long-Evans有帽大鼠进行了一系列神经生理学测试，这些大鼠分别用剂量为100mg/kg的2-、3-或4-甲基吡啶进行处理，该剂量约为腹腔注射半数致死量的一半。测试包括感觉功能测量（配对脉冲闪光诱发电位、图形反转诱发电位和脑干听觉诱发电反应）和大脑兴奋性测量（戊四氮惊厥和海马后放电）。一般来说，用2-和3-甲基吡啶处理的大鼠比用4-甲基吡啶处理的大鼠受影响更大。观察到的变化在许多方面与给予抑制性化合物后观察到的变化相似：诱发电位潜伏期延长和戊四氮惊厥潜伏期延长。然而，并非所有结果都与先前观察到的中枢神经系统抑制模式一致。
