Australian Institute for Bioengineering and Nanotechnology, UQ-JLU Joint Research Centre for Future Materials, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
Angew Chem Int Ed Engl. 2020 Oct 26;59(44):19610-19617. doi: 10.1002/anie.202006861.
Aluminum-containing adjuvants used in vaccine formulations suffer from low cellular immunity, severe aggregation, and accumulation in the brain. Conventional aluminosilicates widely used in the chemical industry focus mainly on acidic sites for catalytic applications, but they are rarely used as adjuvants. Reported here is an innovative "ligand-assisted steric hindrance" strategy to create a high density of six-coordinate Al-OH groups with basicity on dendritic mesoporous silica nanoparticles as new nanoadjuvants. Compared to four-coordinate Al-modified counterparts, Al-OH-rich aluminosilicate nanoadjuvants enhance cellular delivery of antigens and provoke stronger cellular immunity. Moreover, the aluminum accumulation in the brain is more reduced than that with a commercial adjuvant. These results show that coordination chemistry can be used to control the adjuvanticity, providing new understanding in the development of next-generation vaccine adjuvants.
铝佐剂在疫苗配方中存在细胞免疫原性低、严重聚集和在大脑中积累等问题。传统的铝硅酸盐在化工行业中主要集中在用于催化应用的酸性位，但很少用作佐剂。本文报道了一种创新的“配体辅助空间位阻”策略，用于在树状介孔硅纳米粒子上构建具有碱性的六配位 Al-OH 基团，作为新型纳米佐剂。与四配位 Al 修饰的对应物相比，富含 Al-OH 的铝硅酸盐纳米佐剂增强了抗原的细胞传递，并引发了更强的细胞免疫。此外，与商用佐剂相比，铝在大脑中的积累也有所减少。这些结果表明，配位化学可用于控制佐剂的效力，为新一代疫苗佐剂的开发提供了新的认识。
