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Variation of CCR5AS lncRNA Enhances HIV-1 Infection Through Regulation of CCR5 Expression.

作者信息

Zou Sen

机构信息

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

Viral Immunol. 2020 Oct;33(8):536-538. doi: 10.1089/vim.2020.0034. Epub 2020 Sep 1.

DOI:10.1089/vim.2020.0034
PMID:32877293
Abstract

The long noncoding RNA (lncRNA), which could bind to target DNA, RNA, or protein, plays a vital role in the pathogenesis of viral replication and disease progression. Exploring how lncRNA regulates HIV infection is crucial for studying the pathogenesis, disease progression, and effective treatment of AIDS. Recently, Kulkarni convincingly provided a molecular basis for association between CCR5AS lncRNA and outcome of HIV infection. Such results open a new avenue for the treatment and prevention of viral infections. In this study, we retell this story for a broad audience about how a new lncRNA enhances HIV-1 infection in easy-to-understand and jargon-free language.

摘要

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