Hof H, Tintelnot K, Pulverer G
Institut für Hygiene und Mikrobiologie, Universität Würzburg.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Jan;267(3):395-403. doi: 10.1016/s0176-6724(88)80056-7.
Killed bacterial cells of Propionibacterium granulosum KP-45 were found to be potent modifiers of non-specific resistance of mice against infection with either Listeria monocytogenes or Salmonella typhimurium. Injection of P. granulosum 7 days prior to infection resulted in marked splenomegaly. Disseminated acute inflammatory foci were found histologically in the liver. These mice were apparently less susceptible to infection, since definitely lower bacterial counts were determined. Simultaneous application of both P. granulosum KP-45 and L. monocytogenes resulted, however, in increased susceptibility of mice to infection, since definitely higher bacterial counts were found and the inflammatory reaction to infection was markedly enhanced.
已发现颗粒丙酸杆菌KP - 45的灭活细菌细胞是小鼠对单核细胞增生李斯特菌或鼠伤寒沙门氏菌感染的非特异性抵抗力的有效调节剂。在感染前7天注射颗粒丙酸杆菌会导致明显的脾肿大。组织学检查发现肝脏中有弥漫性急性炎症病灶。这些小鼠显然对感染的易感性较低，因为测定的细菌数量明显较少。然而，同时应用颗粒丙酸杆菌KP - 45和单核细胞增生李斯特菌会导致小鼠对感染的易感性增加，因为发现细菌数量明显更高，并且对感染的炎症反应明显增强。
