Guggenheim M A, Baron S
J Infect Dis. 1977 Jul;136(1):50-8. doi: 10.1093/infdis/136.1.50.
Fifteen children ranging in age from one and one-half to 14 years received intravenous polyriboinosinic-polyribocytidylic acid [poly (I)-poly (C)], an interferon inducer. The patients all had serious neurologic illness either directly or circumstatially related to viral infection. Peak titers of interferon in serum ranged from 8 to 500 units/ml in response to doses of poly (I)-poly (C) of 0.1-1.0 mg/kg. Serum interferon persisted for less than or equal to 24 hr after induction. Hyporesponsiveness to a second dose of poly (I)-poly (C) persisted for seven days after initial induction, after which time full response again occurred. The half-life of poly (I) poly (C) in plasma as measured in three patients was less than 30 min. poly (I-poly(C) appears to be safe when given intravenously, but the low titers of interferon induced may limit its clinical usefulness as an antiviral drug.
15名年龄在1岁半至14岁之间的儿童接受了静脉注射聚肌胞苷酸[聚（I）-聚（C）]，一种干扰素诱导剂。这些患者均患有与病毒感染直接或间接相关的严重神经系统疾病。在给予0.1 - 1.0mg/kg剂量的聚（I）-聚（C）后，血清中干扰素的峰值滴度范围为8至500单位/毫升。诱导后血清干扰素持续时间小于或等于24小时。初次诱导后，对第二剂聚（I）-聚（C）的低反应性持续7天，之后再次出现完全反应。在三名患者中测得聚（I）-聚（C）在血浆中的半衰期小于30分钟。静脉注射聚（I）-聚（C）似乎是安全的，但诱导产生的干扰素滴度较低可能会限制其作为抗病毒药物的临床应用。
